Association between metabolically healthy obesity and atrial fibrillation: A systematic review and meta-analysis of longitudinal studies

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2025-04-01 DOI:10.1016/j.dsx.2025.103228

Xiao Liu , Jitao Ling , Yifan Wu , Huilei Zhao , Yuzhe Hu , Zhiwei Yan , Wengen Zhu , Peng Yu , Jinfeng Wang , Yuling Zhang , Tommaso Bucci , Gregory Y.H. Lip

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引用次数: 0

Abstract

Introduction

Obesity is not a single diagnosis, and the association of ‘metabolically unhealthy’ obesity with cardiovascular disease is well-described. However, the relationship between metabolically healthy obesity (MHO) and atrial fibrillation (AF) is still debated.

Objective

Our objective is to investigate the association between MHO and the risk of AF.

Methods

A comprehensive search of databases, including PubMed, EMBASE, Web of Science, and the Cochrane Library regarding longitudinal studies of MHO and risk of AF was performed. Random effects were used to pool the effect estimates.

Results

Nine cohort studies comprising 4,250,557 participants were included. The pooled results revealed that individuals with MHO were associated with a greater incidence of AF than those with a metabolically healthy normal weight (HR: 1.34, 95 % CI: 1.26 to 1.42) with moderate certainty according to the Grading of Recommendations Assessment, Development, and Evaluation assessment. Individuals with MHO were associated with a lower risk of AF compared with participants with metabolically unhealthy obesity (RR: 0.48, 95 % CI: 0.36 to 0.64). Individuals with MHO were not significantly associated with the risk of AF as compared to metabolically unhealthy normal weight (HR: 1.04, 95 % CI: 0.89 to 1.22).

Conclusion

MHO is associated with a greater incidence of AF, highlighting the importance of weight reduction in individuals without metabolic disorders in reducing the risk of AF.

Registration

PROSPERO - registration number CRD42023432195.

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代谢健康肥胖与房颤之间的关系：纵向研究的系统回顾和荟萃分析

肥胖症不是一种单一的诊断，“代谢不健康”的肥胖症与心血管疾病之间的关联已经得到了很好的描述。然而，代谢健康型肥胖（MHO）与心房颤动（AF）之间的关系仍存在争议。方法对PubMed、EMBASE、Web of Science、Cochrane Library等数据库进行综合检索，对MHO与房颤风险的纵向研究进行分析。随机效应用于汇总效应估计。结果纳入9项队列研究，共纳入4250,557名受试者。综合结果显示，根据分级推荐评估、发展和评价评估，与代谢健康的正常体重患者相比，MHO患者的房颤发生率更高（HR: 1.34, 95% CI: 1.26至1.42）。与代谢不健康的肥胖患者相比，MHO患者发生房颤的风险较低（RR: 0.48, 95% CI: 0.36至0.64）。与代谢不健康的正常体重相比，患有MHO的个体与房颤的风险没有显著相关（HR: 1.04, 95% CI: 0.89至1.22）。结论：mho与房颤发生率增高相关，这凸显了在无代谢紊乱的个体中减轻体重对于降低房颤风险的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.