{"title":"Unveiling the role of luteolin as a promising bioactive for wound healing","authors":"Sandeep Prakash , Akash Ved , Shikha Srivastava","doi":"10.1016/j.prenap.2025.100233","DOIUrl":null,"url":null,"abstract":"<div><div>Natural goods and human health are intimately related. Luteolin (LUT), belonging to polyphenolic flavonoid compound found to be abundant in fruits, vegetables, flowers, and plants. Notably, LUT has a range of advantageous pharmacological characteristics and has a great deal of promise for therapeutic use, especially in the areas of anticancer, anti-convulsion, diabetic management, anti-inflammatory, neuroprection, anti-oxidation, and anti-cardiovascular. The possible mode of action has been partially deciphered, involving the involvement of many mechanisms such as NF-κB, toll-like receptor, MAPK, Wnt/β-catenin, PI3K/Akt, AMPK/mTOR, and Nrf-2. The goal of the review was to thoroughly compile all pertinent data on LUT's as best source for wound healing and its natural sources, pharmaceutical effects, therapeutic and preventative potential, and possible mechanisms. The purpose of the study was providing a theoretical framework for the ongoing advancement and utilization of LUT for wound healing.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100233"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S295019972500093X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Natural goods and human health are intimately related. Luteolin (LUT), belonging to polyphenolic flavonoid compound found to be abundant in fruits, vegetables, flowers, and plants. Notably, LUT has a range of advantageous pharmacological characteristics and has a great deal of promise for therapeutic use, especially in the areas of anticancer, anti-convulsion, diabetic management, anti-inflammatory, neuroprection, anti-oxidation, and anti-cardiovascular. The possible mode of action has been partially deciphered, involving the involvement of many mechanisms such as NF-κB, toll-like receptor, MAPK, Wnt/β-catenin, PI3K/Akt, AMPK/mTOR, and Nrf-2. The goal of the review was to thoroughly compile all pertinent data on LUT's as best source for wound healing and its natural sources, pharmaceutical effects, therapeutic and preventative potential, and possible mechanisms. The purpose of the study was providing a theoretical framework for the ongoing advancement and utilization of LUT for wound healing.
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