Sex differences in the mediation of the MASLD - Depression association by fat distribution in U.S. adults

IF 2.1 4区心理学 Q2 PSYCHOLOGY, EXPERIMENTAL

Acta Psychologica Pub Date : 2025-04-29 DOI:10.1016/j.actpsy.2025.105041

Changhuai He , Liuxin Zhou , Tianming Gao , Runmin Cao , Chuanqi Cai , Guoqing Jiang

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引用次数: 0

Abstract

Purpose

This study investigates the intricate relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and depression, emphasizing the mediating role of body fat distribution, particularly in female.

Methods

We analyzed the pairwise relationship among body fat distribution (android fat and gynoid fat), MASLD, and depression within a robust, ethnically diverse sample (n = 3332) drawn from the National Health and Nutrition Examination Survey (NHANES).

Results

Studies have indicated that individuals with depression or MASLD exhibit significantly higher levels of android fat compared to those without these health issues. Even after controlling for confounding factors, MASLD maintained significant correlations with both depression and body fat distribution (android fat and gynoid fat). Notably, sex moderated the relationship between MASLD, depression, and body fat distribution. Among the potential mediators of the effect of MASLD on depression, android fat emerged as a significant mediator, accounting for 16.6 % of the variance and yielding statistically significant results (p < 0.05). This mediating effect was particularly pronounced in female subjects, with a mediating proportion of 17.83 %, which was also statistically significant (p < 0.05). However, it was not observed in males.

Conclusions

This study reveals an important association between MASLD and depression, and android fat distribution is a potential mediator in this relationship, with a particularly pronounced effect on the female population.

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性别差异在美国成人脂肪分布介导MASLD -抑郁关联中的作用

目的探讨代谢功能障碍相关脂肪变性肝病（MASLD）与抑郁症之间的复杂关系，强调体脂分布的中介作用，特别是在女性中。方法我们从全国健康与营养检查调查（NHANES）中抽取了一个强大的、不同种族的样本（n = 3332），分析了体脂分布（雄性脂肪和雌性脂肪）、MASLD和抑郁症之间的两两关系。研究表明，与没有这些健康问题的人相比，抑郁症或MASLD患者的安卓脂肪水平明显更高。即使在控制了混杂因素后，MASLD仍与抑郁症和体脂分布（雄性脂肪和雌性脂肪）保持显著相关。值得注意的是，性别调节了MASLD、抑郁和体脂分布之间的关系。在MASLD对抑郁影响的潜在中介中，android fat成为一个显著的中介，占方差的16.6%，产生具有统计学意义的结果(p <；0.05)。这种中介效应在女性受试者中尤为明显，中介比例为17.83%，也具有统计学意义(p <；0.05)。然而，在男性中没有观察到这种情况。结论本研究揭示了MASLD与抑郁症之间的重要关联，而脂肪分布是这种关系的潜在中介，对女性人群的影响尤为显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychologica PSYCHOLOGY, EXPERIMENTAL-

CiteScore

3.00

自引率

5.60%

发文量

274

审稿时长

36 weeks

期刊介绍： Acta Psychologica publishes original articles and extended reviews on selected books in any area of experimental psychology. The focus of the Journal is on empirical studies and evaluative review articles that increase the theoretical understanding of human capabilities.