Host factors influencing sexual differentiation and transmission of Plasmodium: A comprehensive review

IF 2.1 3区医学 Q2 PARASITOLOGY

Acta tropica Pub Date : 2025-04-25 DOI:10.1016/j.actatropica.2025.107634

Yanlin Li , Jingjing Tang , Wei Tang , Cong Liu , Zhenkui Li

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Abstract

Malaria, a severe parasitic disease caused by Plasmodium infections, remains a major global health challenge. Efforts to eradicate malaria are complicated by the parasite’s intricate life cycle, which alternates between vertebrate hosts and mosquito vectors. Host-derived factors and parasite-sourced components exert crucial roles in regulating this biological process. This review explores the critical role of host-derived factors in shaping Plasmodium sexual differentiation and transmission. We examine how vertebrate and mosquito host-specific factors either promote or restrict parasite development, influencing the transition from vertebrates to mosquitoes. Understanding these host-mediated mechanisms is crucial for developing novel transmission-blocking strategies to reduce malaria prevalence. By highlighting key interactions between hosts and parasites, this review provides insights into potential interventions that could disrupt Plasmodium transmission and contribute to malaria control efforts.

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影响疟原虫性别分化和传播的宿主因素综述

疟疾是一种由疟原虫感染引起的严重寄生虫病，仍然是一项重大的全球卫生挑战。这种寄生虫在脊椎动物宿主和蚊子载体之间交替，其复杂的生命周期使根除疟疾的努力变得复杂。宿主来源的因子和寄生虫来源的成分在调节这一生物过程中起着至关重要的作用。本文综述了宿主源性因子在塑造疟原虫性分化和传播中的关键作用。我们研究了脊椎动物和蚊子宿主特异性因子如何促进或限制寄生虫的发育，影响从脊椎动物到蚊子的转变。了解这些宿主介导的机制对于制定新的传播阻断策略以减少疟疾流行至关重要。通过强调宿主和寄生虫之间的关键相互作用，本综述为可能破坏疟原虫传播和促进疟疾控制工作的潜在干预措施提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta tropica 医学-寄生虫学

CiteScore

5.40

自引率

11.10%

发文量

383

审稿时长

37 days

期刊介绍： Acta Tropica, is an international journal on infectious diseases that covers public health sciences and biomedical research with particular emphasis on topics relevant to human and animal health in the tropics and the subtropics.