Organic Peroxides in Transition-Metal-Free Cyclization and Coupling Reactions (C–C) via Oxidative Transformation

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-04-14 DOI:10.1021/acsomega.4c1157410.1021/acsomega.4c11574

Amin Rezaeifard, Fatemeh Doraghi, Fatemeh Akbari, Bahareh Bari, Ebrahim Kianmehr, Ali Ramazani, Mehdi Khoobi* and Alireza Foroumadi*,

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引用次数: 0

Abstract

Transition-metal-free transformations are recognized as green and sustainable methods for constructing carbon–carbon bonds in organic synthesis. This review describes the application of six organic peroxides, including tert-butyl hydroperoxide (TBHP), di-tert-butyl peroxide (DTBP), tert-butyl peroxybenzoate (TBPB), benzoyl peroxide (BPO), dialauroyl peroxide (DLP), and diguyl peroxide (DCP), in C–C bond construction, highlighting selected examples and mechanisms of challenging transformations. Each section concludes with a detailed overview of suitable reagents for various coupling reactions and strengths and weaknesses of the reported works. This work aims to inspire further innovations in transition-metal-free oxidative transformations, promoting sustainable and eco-friendly chemical processes and paving the way for new peroxide-based organic synthesis methods.

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有机过氧化物氧化转化过渡-无金属环化和偶联反应(C-C

无过渡金属转化被认为是有机合成中构建碳-碳键的绿色和可持续的方法。本文综述了六种有机过氧化物，包括氢过氧化物叔丁基（thbhp）、过氧化二叔丁基（DTBP）、过氧苯甲酸叔丁基（TBPB）、过氧化苯甲酰（BPO）、过氧化二脲基（DLP）和过氧化二脲基（DCP），在C-C键构建中的应用，重点介绍了一些具有挑战性的转化例子和机制。每一节最后都详细概述了各种偶联反应的合适试剂以及所报道作品的优缺点。这项工作旨在激发过渡金属氧化转化的进一步创新，促进可持续和环保的化学过程，并为新的过氧化物基有机合成方法铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.