Yeast-Derived Manganese and Zinc Metal–Organic Framework Composite as a Vaccine Adjuvant for Enhanced Humoral and Cellular Immune Responses

IF 15.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ACS Nano Pub Date : 2025-04-28 DOI:10.1021/acsnano.5c04365

Lanlan Zheng, Zi Wang, Hang Liu, Nianxiang Wang, Junjun Liu, Mengyao Ma, Xinhao Jia, Mengwei Qian, Yidan Liu, Muzi Li, Zhanyong Wei, Yuqiang Xiang

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Abstract

To control pandemics, a universal adjuvant platform that can deliver antigens and stimulate the immune system that rapidly elicits humoral and cellular immune responses is needed, especially one that can stimulate the body’s immune system to produce protective immunological memory. However, the design, composition, and mechanism of adjuvants have presented considerable challenges. The types of adjuvants currently approved in clinics are rare and are far from meeting the requirements of vaccine development. In this study, we prepared a yeast-derived manganese and zinc metal–organic framework (MOF) composite particle adjuvant by self-assembling Mn-MOF-74 and ZIF-8 on the surface of yeast and named it yeast@Mn-MOF-74@ZIF-8 (yMZ). yMZ was able to promote the maturation and activation of dendritic cells (DCs), enhance the uptake and presentation of antigens by DCs, increase the production of adaptive immune cells with memory, enhance humoral and cellular immune responses, and promote the activation of the germinal center. Additionally, yMZ allowed for effective control of antigen release and exhibited good biosafety in vivo. In this study, yMZ showed good adjuvant effects on subunits and inactivated vaccines, indicating that it is a next-generation adjuvant candidate with potential application prospects.

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酵母衍生的锰锌金属-有机骨架复合材料作为疫苗佐剂增强体液和细胞免疫反应

为了控制流行病，需要一种通用的佐剂平台，它可以传递抗原并刺激免疫系统，从而迅速引发体液和细胞免疫反应，特别是可以刺激人体免疫系统产生保护性免疫记忆的佐剂平台。然而，佐剂的设计、组成和作用机制提出了相当大的挑战。目前临床批准的佐剂种类很少，远远不能满足疫苗开发的要求。本研究通过在酵母表面自组装Mn-MOF-74和ZIF-8，制备了酵母衍生的锰锌金属有机骨架（MOF）复合颗粒佐剂，命名为yeast@Mn-MOF-74@ZIF-8 （yMZ）。yMZ能够促进树突状细胞的成熟和活化，增强树突状细胞对抗原的摄取和呈递，增加具有记忆的适应性免疫细胞的产生，增强体液和细胞免疫应答，促进生发中心的活化。此外，yMZ能有效控制抗原释放，具有良好的体内生物安全性。本研究中，yMZ对亚基和灭活疫苗均表现出良好的佐剂作用，是具有潜在应用前景的新一代佐剂候选物。

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来源期刊

ACS Nano 工程技术-材料科学：综合

CiteScore

26.00

自引率

4.10%

发文量

1627

审稿时长

1.7 months

期刊介绍： ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.