The Impact of Cardiometabolic Index on Cardiovascular Disease Risk Among Diabetic Patients: Evidence From Two National Cohorts

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes/Metabolism Research and Reviews Pub Date : 2025-04-28 DOI:10.1002/dmrr.70044

Changxing Liu, Zhirui Zhang, Tianwei Meng, Boyu Wang, Chengjia Li, Ximing Yu, Xulong Zhang

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Abstract

Background

This study investigates the relationship between the Cardiometabolic Index (CMI) and cardiovascular disease (CVD) risk in diabetic populations using data from the National Health and Nutrition Examination Survey (NHANES) and the China Health and Retirement Longitudinal Study (CHARLS). Understanding the predictive role of CMI in assessing CVD risk is essential for enhancing preventive strategies in diabetic patients.

Methods

A cross-sectional analysis was conducted on diabetic participants from NHANES (2005–2018) and CHARLS (2011). CMI was calculated based on the waist-to-height ratio and the triglyceride-to-HDL-C ratio. Multivariable logistic regression models and restricted cubic spline analyses were utilised to evaluate the associations between CMI and CVD risk, adjusting for demographic and clinical covariates.

Results

In the NHANES cohort (n = 2044), a higher CMI was significantly associated with an increased risk of CVD after adjusting for confounding factors (OR = 2.01, p = 0.0074). Similarly, in the CHARLS cohort (n = 3964), a higher CMI was linked to an elevated CVD risk (OR = 1.45, p = 0.009). Subgroup analyses demonstrated consistent results across various age, gender and health status subgroups. The restricted cubic spline analysis revealed significant non-linear trends between CMI and CVD risk in both cohorts (p < 0.05).

Conclusion

CMI is a robust and independent predictor of CVD risk among diabetic individuals across different populations. These findings highlight the potential clinical value of incorporating CMI into routine assessments to identify high-risk diabetic patients. Future longitudinal studies are needed to further validate these findings and explore the underlying mechanisms.

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心血管代谢指数对糖尿病患者心血管疾病风险的影响：来自两个国家队列的证据

本研究利用全国健康与营养调查（NHANES）和中国健康与退休纵向研究（CHARLS）的数据，探讨糖尿病人群心脏代谢指数（CMI）与心血管疾病（CVD）风险之间的关系。了解CMI在评估CVD风险中的预测作用对于加强糖尿病患者的预防策略至关重要。方法对NHANES（2005-2018）和CHARLS（2011）的糖尿病参与者进行横断面分析。CMI是根据腰高比和甘油三酯与hdl - c的比值计算的。多变量logistic回归模型和限制三次样条分析用于评估CMI和CVD风险之间的关系，调整了人口统计学和临床协变量。结果在NHANES队列中（n = 2044），校正混杂因素后，较高的CMI与CVD风险增加显著相关（OR = 2.01, p = 0.0074）。同样，在CHARLS队列中（n = 3964），较高的CMI与CVD风险升高相关（OR = 1.45, p = 0.009）。亚组分析表明，不同年龄、性别和健康状况亚组的结果一致。限制性三次样条分析显示，两组患者CMI和CVD风险之间存在显著的非线性趋势(p <；0.05)。结论CMI是不同人群糖尿病患者CVD风险的可靠且独立的预测因子。这些发现强调了将CMI纳入常规评估以识别高危糖尿病患者的潜在临床价值。未来的纵向研究需要进一步验证这些发现并探索潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢

CiteScore

17.20

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.