Research Progress of Plasma Cell Mastitis

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2025-04-27 DOI:10.1002/iid3.70199

Zhebin Liang, Lifeng Zhang

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引用次数: 0

Abstract

Background

Plasma cell mastitis (PCM), also termed mammary duct ectasia, is a chronic nonbacterial inflammatory disease characterized by mammary duct dilation and plasma cell infiltration. Due to its varied and nonspecific clinical presentation, PCM is frequently misdiagnosed as breast cancer, complicating clinical management.

Objectives

This review aims to summarize recent advances in the understanding of PCM, focusing on its etiology, clinical manifestations, diagnosis, and treatment strategies, as well as clarifying differential diagnostic points with granulomatous mastitis (GLM).

Methods

We reviewed recent literature highlighting clinical characteristics, diagnostic approaches, and therapeutic options related to PCM, including comparative studies addressing differences between PCM and GLM.

Discussion

Recent progress has enhanced understanding of PCM's clinical and pathological features, yet distinguishing PCM from GLM remains clinically challenging due to overlapping presentations. An integrated approach involving clinical evaluation, imaging modalities, and histopathological examination is recommended to improve diagnostic accuracy and clinical outcomes.

Conclusion

Further investigation into the pathogenesis of PCM is essential for developing more precise diagnostic criteria and effective treatments, ultimately improving patient prognosis and reducing misdiagnosis.

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浆细胞性乳腺炎的研究进展

浆细胞性乳腺炎（PCM），也称为乳腺导管扩张，是一种以乳腺导管扩张和浆细胞浸润为特征的慢性非细菌性炎症性疾病。由于其临床表现的多样性和非特异性，PCM经常被误诊为乳腺癌，使临床治疗复杂化。本文综述了近年来对PCM的认识进展，重点介绍了PCM的病因、临床表现、诊断和治疗策略，并明确了与肉芽肿性乳腺炎（GLM）的鉴别诊断要点。方法我们回顾了最近的文献，强调了与PCM相关的临床特征、诊断方法和治疗选择，包括PCM和GLM之间差异的比较研究。最近的进展增强了对PCM临床和病理特征的理解，但由于重叠的表现，将PCM与GLM区分开来仍然具有临床挑战性。建议采用包括临床评估、成像方式和组织病理学检查在内的综合方法来提高诊断准确性和临床结果。结论深入研究PCM的发病机制，有助于制定更准确的诊断标准和有效的治疗方法，最终改善患者预后，减少误诊。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology