Estimated Incidence Rate of Specific Types of Cardiovascular and Respiratory Hospitalizations Attributable to Respiratory Syncytial Virus Among Adults in Germany Between 2015 and 2019

IF 4.3 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2025-04-28 DOI:10.1111/irv.70097

Caihua Liang, Aleksandra Polkowska-Kramek, Caroline Lade, Lea J. Bayer, Robin Bruyndonckx, Bennet Huebbe, Worku Biyadgie Ewnetu, Pimnara Peerawaranun, Maribel Casas, Thao Mai Phuong Tran, Gordon Brestrich, Christof von Eiff, Bradford D. Gessner, Elizabeth Begier, Gernot Rohde

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引用次数: 0

Abstract

Background

RSV incidence in adults is frequently underestimated due to non-specific symptomatology, limited standard-of-care testing, and lower test sensitivity compared to infants. We conducted a retrospective observational study to estimate RSV-attributable incidence of specific types of cardiorespiratory hospitalizations among adults in Germany between 2015 and 2019.

Methods

Information on hospitalizations and the number of people at risk of hospitalization (denominator) was gathered from a Statutory Health Insurance database. A quasi-Poisson regression model accounting for periodic and aperiodic time trends and virus activity was fitted to estimate the RSV-attributable incidence rate (IR) of four specific cardiovascular hospitalizations (arrhythmia, ischemic heart diseases, chronic heart failure exacerbations, and cerebrovascular diseases) and four specific respiratory hospitalizations (influenza/pneumonia, bronchitis/bronchiolitis, chronic lower respiratory tract diseases, and upper respiratory tract diseases).

Results

The estimated RSV-attributable IRs of hospitalizations generally increased with age. Among estimated cardiovascular hospitalizations in adults aged ≥ 60 years, arrhythmia and ischemic heart diseases accounted for the highest incidence of RSV-attributable events, followed by chronic heart failure exacerbation, with annual IR ranges of 157–260, 133–214, and 105–169 per 100,000 person-years, respectively. The most frequent RSV-attributable respiratory hospitalizations in adults aged ≥ 60 years were estimated for chronic lower respiratory tract diseases and bronchitis/bronchiolitis, with annual IR ranges of 103–168 and 77–122 per 100,000 person-years, respectively.

Conclusions

RSV causes a considerable burden of respiratory and cardiovascular hospitalizations in adults in Germany, similar to other respiratory viruses (e.g., influenza and SARS-CoV-2). This highlights the need to implement effective prevention strategies, especially for older adults.

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2015年至2019年德国成年人因呼吸道合胞病毒导致的特定类型心血管和呼吸道住院的估计发病率

背景：与婴儿相比，由于非特异性症状、有限的标准护理检测和较低的检测敏感性，成人RSV发病率经常被低估。我们进行了一项回顾性观察性研究，以估计2015年至2019年德国成年人中特定类型心肺住院的rsv归因发生率。方法从法定健康保险数据库中收集住院情况和住院风险人数（分母）信息。拟合考虑周期和非周期时间趋势和病毒活性的准泊松回归模型，估计4种特定心血管住院（心律失常、缺血性心脏病、慢性心力衰竭加重和脑血管疾病）和4种特定呼吸系统住院（流感/肺炎、支气管炎/细支气管炎、慢性下呼吸道疾病、慢性下呼吸道疾病）的rsv归因发病率（IR）。以及上呼吸道疾病)。结果住院患者的rsv归因系数一般随年龄增加而增加。在估计的60岁以上成人心血管住院中，心律失常和缺血性心脏病占rsv可归因于事件的最高发生率，其次是慢性心力衰竭加重，年IR范围分别为157-260、133-214和105-169 / 100,000人年。在年龄≥60岁的成年人中，最常见的呼吸道住院是慢性下呼吸道疾病和支气管炎/细支气管炎，年IR范围分别为103-168和77-122 / 100,000人年。结论：与其他呼吸道病毒（如流感和SARS-CoV-2）类似，RSV在德国成年人中造成相当大的呼吸道和心血管住院负担。这突出表明需要实施有效的预防战略，特别是对老年人。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.