Diagnosis and Treatment of Primary Tracheobronchial Tumors

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-04-27 DOI:10.1002/cam4.70893

Chen Shu, Yu-jian Liu, Kai-fu Zheng, Xi-yang Tang, Meng-chao Li, Yang Shen, Yu-long Zhou, Wei-guang Du, Nan Ma, Jin-bo Zhao

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Abstract

Background

Primary tracheobronchial tumors (PTBTs) are rare but life-threatening, accounting for approximately 0.2% of all respiratory neoplasms. Owing to their nonspecific clinical symptoms, PTBTs are often initially misdiagnosed as bronchial asthma or bronchitis in the early stages. In addition, standardized treatments for PTBTs are currently lacking.

Aims

This study aimed to provide a comprehensive review of this diagnostic challenge and treatment modalities of PTBTs.

Methods

Drawing on the latest literature and clinical guidelines, we carried out a comprehensive and systematic analysis of PTBTs, focusing on diagnostic modalities, and evidence-based treatment options.

Results and Conclusions

Primary diagnostic methods for PTBTs include pulmonary function tests, chest radiography, computed tomography, and fiberoptic bronchoscopy. Computed tomography, and fiberoptic bronchoscopy may be the most valuable diagnostic tools for patients with PTBTs or those highly suspected of having PTBTs. Currently, there are no consensus guidelines for PTBTs, and surgery is the most effective method for treating PTBTs if the patients have indications for surgery. In addition, radiotherapy, chemotherapy and interventional therapy may be useful complementary treatments for inoperable patients. Immunotherapy may be a significant management strategy for PTBTs in the future. Further researches should concentrate on both the early identification and enhanced therapeutic management of these tumors to improve survival and diminish morbidity and mortality rates by investigating the optimal design of systematic therapy.

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原发性气管支气管肿瘤的诊断与治疗

原发性气管支气管肿瘤（ptbt）罕见但危及生命，约占所有呼吸道肿瘤的0.2%。由于其非特异性临床症状，ptbt在早期常被误诊为支气管哮喘或支气管炎。此外，目前还缺乏对ptbt的标准化治疗。本研究旨在对ptbt的诊断挑战和治疗方式进行全面的综述。方法根据最新文献和临床指南，对ptbt进行全面系统的分析，重点分析诊断方式和循证治疗方案。结果与结论ptbt的主要诊断方法包括肺功能检查、胸片、计算机断层扫描和纤维支气管镜检查。计算机断层扫描和纤维支气管镜检查可能是ptbt患者或高度怀疑ptbt患者最有价值的诊断工具。目前，ptbt的治疗尚无一致的指南，如果患者有手术指征，手术是治疗ptbt最有效的方法。此外，放疗、化疗和介入治疗可作为不能手术患者的辅助治疗。免疫治疗可能是未来治疗ptbt的重要策略。进一步的研究应集中在这些肿瘤的早期识别和加强治疗管理，通过研究系统治疗的最佳设计来提高生存率，降低发病率和死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.