{"title":"Preparation of quercetin long-circulating liposomes and their therapeutic effect on diabetic peripheral neuropathy","authors":"Jing Wang, Mingjie Gong, Gongbing Tu, Bing Luo, Qilong Wang, Hui Ding, Xiulin Liang, Jie Chen","doi":"10.1007/s11051-025-06323-0","DOIUrl":null,"url":null,"abstract":"<div><p>Diabetic peripheral neuropathy (DPN) is a prevalent chronic complication of diabetes mellitus, which often results in significant patient discomfort. The objective of this study was to enhance the solubility and bioavailability of quercetin by loading quercetin into long-circulating liposomes (Q-LL) to ultimately achieve the goal of enhancing the therapeutic impact of quercetin on DPN. The Q-LL was synthesized using the film dispersion method, followed by a comprehensive series of characterizations as well as in vitro release and in vivo pharmacokinetic studies. Subsequently, the DPN rat model was established before the administration of free quercetin and Q-LL to the rats. The potential mechanism of Q-LL in the treatment of DPN was postulated by detecting levels of blood lipid, oxidative stress, and inflammation in rats after 4 weeks of oral administration. Q-LLs were successfully developed, which had a particle size of 110.93 ± 1.49 nm, a PDI of 0.179 ± 0.012, a zeta potential of − 25.37 ± 0.31 mV, an encapsulation efficiency (EE)% of 93.57 ± 0.19%, and a drug loading (DL)% of 9.66 ± 0.12%, as well as displayed a sustained release effect. This Q-LL significantly increased the solubility and in vivo circulation time of quercetin, thus significantly improving the bioavailability of quercetin. Q-LL may alleviate DPN by reducing levels of blood lipid, oxidative stress, and inflammatory response. Overall, Q-LL may offer a new strategy for the potential extension of the in vivo circulation of quercetin and enhancement of its bioavailability for DPN treatment.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 5","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06323-0","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetic peripheral neuropathy (DPN) is a prevalent chronic complication of diabetes mellitus, which often results in significant patient discomfort. The objective of this study was to enhance the solubility and bioavailability of quercetin by loading quercetin into long-circulating liposomes (Q-LL) to ultimately achieve the goal of enhancing the therapeutic impact of quercetin on DPN. The Q-LL was synthesized using the film dispersion method, followed by a comprehensive series of characterizations as well as in vitro release and in vivo pharmacokinetic studies. Subsequently, the DPN rat model was established before the administration of free quercetin and Q-LL to the rats. The potential mechanism of Q-LL in the treatment of DPN was postulated by detecting levels of blood lipid, oxidative stress, and inflammation in rats after 4 weeks of oral administration. Q-LLs were successfully developed, which had a particle size of 110.93 ± 1.49 nm, a PDI of 0.179 ± 0.012, a zeta potential of − 25.37 ± 0.31 mV, an encapsulation efficiency (EE)% of 93.57 ± 0.19%, and a drug loading (DL)% of 9.66 ± 0.12%, as well as displayed a sustained release effect. This Q-LL significantly increased the solubility and in vivo circulation time of quercetin, thus significantly improving the bioavailability of quercetin. Q-LL may alleviate DPN by reducing levels of blood lipid, oxidative stress, and inflammatory response. Overall, Q-LL may offer a new strategy for the potential extension of the in vivo circulation of quercetin and enhancement of its bioavailability for DPN treatment.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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