Evaluation of diffusion properties of polyethylene oxide (PEO) based dosimetric gel

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-04-17 DOI:10.1016/j.radphyschem.2025.112800

Anna Luiza F. Silveira , Iasmin V. Nishibayaski , Rita C.O. Sebastião , André L.S. Castro , Luiz C. Meira-Belo

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引用次数: 0

Abstract

Volumetric chemical dosimetry with gel-based radiation detectors using Fricke or polymer-based materials provides a unique methodology for measuring dose distribution in three dimensions, positioning itself as a promising alternative to the use of radiographic films and ionization chambers in radiotherapy. However, problems such as the heterogeneity of natural gelatinous matrices and diffusion of ferric ions in traditional Fricke gels can lead to significant uncertainties in spatial dose measurements. Therefore, developing new dosimetric gel formulations based on synthetic matrices that offer high stability, sensitivity, reproducibility, and ease of production is crucial. The main objective of this study was to standardize the production method of a chemical dosimeter based on polyethylene oxide (FX-PEO) and analyze the stability of its response as well as other essential factors to validate its performance using UV-Vis spectrophotometry for optical absorbance and nuclear magnetic resonance. Preliminary results demonstrate that the diffusion coefficient of the PEO-based polymer Fricke gel is approximately 45 % lower than that of the Fricke Xylenol gel, significantly contributing to the enhanced performance of the detector in radiotherapy applications.

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聚氧聚乙烯（PEO）剂量测定凝胶扩散性能的评价

使用Fricke或聚合物基材料的凝胶基辐射探测器的体积化学剂量学提供了一种独特的方法来测量三维剂量分布，将其定位为放射照相胶片和电离室在放射治疗中使用的有前途的替代方法。然而，天然凝胶基质的不均匀性和传统Fricke凝胶中铁离子的扩散等问题会导致空间剂量测量的不确定性。因此，开发基于合成基质的新型剂量测定凝胶配方，提供高稳定性、灵敏度、可重复性和易于生产是至关重要的。本研究的主要目的是标准化聚乙烯氧化物（FX-PEO）化学剂量计的生产方法，并利用紫外可见分光光度法和核磁共振法对其响应稳定性及其他关键因素进行分析，以验证其性能。初步结果表明，peo基聚合物Fricke凝胶的扩散系数比Fricke二甲酚凝胶的扩散系数低约45%，显著提高了探测器在放疗应用中的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.