Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation Pub Date : 2025-04-23 DOI:10.1016/j.brs.2025.04.010

Danielle Lauren Kurtin , Ketevan Alania , Edward Rhodes , Samuel Vincent , Ines R. Violante , Nir Grossman

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引用次数: 0

Abstract

Background

Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acutely modulate activity or FC traces of preceding cognitive tasks.

Objectives

We evaluated whether non-invasive temporal interference (TI) stimulation of the hippocampus can modulate hippocampal resting-state FC traces induced by a preceding hippocampally-dependent task.

Methods

We collected resting-state functional magnetic resonance imaging (rsfMRI) in twenty healthy participants before and after the performance of an associative memory task. Theta-band TI stimulation of the medial and anterior hippocampus, and sham stimulation were delivered during post-task resting state. We used permutation tests to assess differences in pairwise mutual information functional connectivity (miFC) between pre-task rsfMRI vs post-task sham. In edges with significantly different pre-vs post-task miFC, permutation tests assessed the effect of TI on post-task miFC.

Results

MiFC was significantly lower in several functional networks during post-task sham compared to pre-task baseline, including the hippocampal-connected and task-related Anterior Temporal (AT) and Posterior Medial (PM) networks. TI stimulation of the hippocampus during post-task resting state increased the miFC in the hippocampal AT and PM networks as well as other functional networks.

Conclusions

Non-invasive TI stimulation of the hippocampus during the resting state acutely modulated FC traces related to preceding hippocampal-dependent memory tasks.

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静息状态连通性的任务相关变化受到时间干扰刺激的影响

大脑网络活动和功能连接（FC）等记忆状态指标受到先前认知任务（如记忆形成）的影响。脑刺激可以调节静息状态下的脑网络活动和FC。然而，尚不清楚它是否能剧烈调节活动或前认知任务的FC痕迹。目的评估海马非侵入性颞叶干扰（TI）刺激是否可以调节前一个海马依赖任务诱导的海马静息状态FC痕迹。方法采集20名健康被试在执行联想记忆任务前后的静息状态功能磁共振成像（rsfMRI）。在任务后静息状态下，对海马内侧和前部进行Theta-band刺激和假刺激。我们使用排列测试来评估任务前rsfMRI与任务后sham之间两两互信息功能连接（miFC）的差异。在任务前后miFC差异显著的边缘上，排列测试评估了TI对任务后miFC的影响。结果与任务前基线相比，任务后假手术期间多个功能网络的smifc显著降低，包括海马连接和任务相关的颞叶前部（AT）和后内侧（PM）网络。任务后静息状态海马的TI刺激增加了海马AT和PM网络以及其他功能网络的miFC。结论静息状态下非侵入性脑电刺激海马急性调节FC痕迹与海马依赖性记忆任务相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Stimulation 医学-临床神经学

CiteScore

13.10

自引率

9.10%

发文量

256

审稿时长

72 days

期刊介绍： Brain Stimulation publishes on the entire field of brain stimulation, including noninvasive and invasive techniques and technologies that alter brain function through the use of electrical, magnetic, radiowave, or focally targeted pharmacologic stimulation. Brain Stimulation aims to be the premier journal for publication of original research in the field of neuromodulation. The journal includes: a) Original articles; b) Short Communications; c) Invited and original reviews; d) Technology and methodological perspectives (reviews of new devices, description of new methods, etc.); and e) Letters to the Editor. Special issues of the journal will be considered based on scientific merit.