The impact of fear of cancer recurrence on anxiety and depression in women with cancer: The chain mediating roles of financial toxicity and psychological distress — A multicenter investigative study

IF 2.4 3区医学 Q1 NURSING

Asia-Pacific Journal of Oncology Nursing Pub Date : 2025-04-14 DOI:10.1016/j.apjon.2025.100699

Lu Liu , Man Liu , Yang Liu , Hang Yi , Zhuoheng Lyu , ShuJun Xing , Yan Liu

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引用次数: 0

Abstract

Objective

This study aimed to explore the impact of fear of cancer recurrence on anxiety and depression in female cancer patients, and to examine the chain mediating roles of financial toxicity and psychological distress in this relationship.

Methods

Between February and July 2024, a total of 417 female cancer patients from top-tier cancer hospitals across 13 regions in China were recruited. Participants completed the Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the Hospital Anxiety and Depression Scale (HADS), the Comprehensive Score for Financial Toxicity (COST), and the Distress Thermometer (DT).

Results

(1) Fear of recurrence, financial toxicity, psychological distress, anxiety, and depression were significantly correlated. (2) Two mediating pathways were identified: a direct path where fear of recurrence increased psychological distress, leading to heightened anxiety and depression; and an indirect chain mediation path wherein fear of recurrence elevated financial toxicity, which in turn intensified psychological distress, ultimately contributing to anxiety and depression.

Conclusions

Health care providers should be aware of the psychological and financial burdens associated with fear of recurrence in women with cancer. Addressing these issues may enhance the effectiveness of psychological interventions, reduce emotional distress, and ultimately improve patients' quality of life.

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癌症复发恐惧对女性癌症患者焦虑和抑郁的影响：经济毒性和心理困扰的连锁中介作用——一项多中心调查研究

目的探讨癌症复发恐惧对女性癌症患者焦虑和抑郁的影响，并探讨经济毒性和心理困扰在这一关系中的连锁中介作用。方法在2024年2月至7月期间，从中国13个地区的顶级肿瘤医院共招募417名女性癌症患者。参与者完成了进展恐惧简短问卷（FoP-Q-SF）、医院焦虑抑郁量表（HADS）、财务毒性综合评分（COST）和困扰温度计（DT）。结果(1)复发恐惧、财务毒性、心理困扰、焦虑和抑郁呈显著相关。(2)发现了两种中介通路：一种是直接通路，即对复发的恐惧增加了心理困扰，导致焦虑和抑郁加剧；在间接的连锁调解路径中，对复发的恐惧增加了财务毒性，这反过来又加剧了心理困扰，最终导致焦虑和抑郁。结论卫生保健人员应了解与癌症复发恐惧相关的心理和经济负担。解决这些问题可以提高心理干预的有效性，减少情绪困扰，并最终改善患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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