Grading risk of microvascular invasion impacts survival in hepatocellular carcinoma patients undergoing adjuvant transarterial chemoembolization: A multicenter study

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso Pub Date : 2025-04-24 DOI:10.1016/j.ejso.2025.110102

Jin-Pian Lu , Jin-Kai Feng , Yang Zhao , Bin Chen , Peng-Ping Li , Chao He , Lin Gong , Ling-Ling Bao

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引用次数: 0

Abstract

Purpose

To investigate the influence of postoperative adjuvant transarterial chemoembolization (PA-TACE) on the prognosis of hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) following liver resection (LR), and explore whether grading risk of MVI can impact the survival of HCC patients undergoing PA-TACE.

Methods

Patients who had HCC with MVI were consecutively enrolled. Overall survival (OS) and recurrence-free survival (RFS) were compared between the PA-TACE and LR groups. Univariate and multivariate analyses were performed to identify independent prognostic factors for these patients. Subgroup survival analysis was conducted using the grading risk of MVI.

Results

The median OS and RFS of the PA-TACE group were significantly longer than the LR group. PA-TACE was associated with significantly better OS (P = 0.032) and RFS (P = 0.023) compared with LR alone. In subgroup analysis, there were no significant differences in prognosis between the PA-TACE and LR groups for HCC patients with low-risk MVI. For HCC patients with high-risk MVI, the PA-TACE group had significantly better prognosis than the LR group (for OS, P = 0.017; for RFS, P = 0.018).

Conclusion

PA-TACE should be performed selectively in HCC patients with high-risk MVI after curative liver resection. Nonetheless, for HCC patients with low-risk MVI, PA-TACE is not recommended.

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微血管侵犯分级风险影响肝细胞癌患者接受辅助经动脉化疗栓塞的生存：一项多中心研究

目的探讨肝切除术（LR）后辅助经动脉化疗栓塞（PA-TACE）对肝细胞癌（HCC）微血管侵犯（MVI）患者预后的影响，探讨MVI分级风险是否会影响PA-TACE患者的生存。方法连续入组肝癌合并MVI患者。比较PA-TACE组和LR组的总生存期（OS）和无复发生存期（RFS）。进行单因素和多因素分析以确定这些患者的独立预后因素。采用MVI分级风险进行亚组生存分析。结果PA-TACE组的中位OS和RFS均明显长于LR组。与单独使用LR相比，PA-TACE与更好的OS （P = 0.032）和RFS （P = 0.023）相关。在亚组分析中，PA-TACE组与LR组对HCC合并低危MVI患者的预后无显著差异。对于HCC合并高危MVI患者，PA-TACE组预后明显优于LR组(OS, P = 0.017；RFS, P = 0.018)。结论肝癌合并高危MVI患者在根治性肝切除术后应选择性行pa - tace治疗。然而，对于低危MVI的HCC患者，不推荐使用PA-TACE。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ejso 医学-外科

CiteScore

6.40

自引率

2.60%

发文量

1148

审稿时长

41 days

期刊介绍： JSO - European Journal of Surgical Oncology ("the Journal of Cancer Surgery") is the Official Journal of the European Society of Surgical Oncology and BASO ~ the Association for Cancer Surgery. The EJSO aims to advance surgical oncology research and practice through the publication of original research articles, review articles, editorials, debates and correspondence.