The association between serum leptin, adiponectin and resistin levels with chronic kidney disease with and without hemodialysis patients

Q3 Medicine

Endocrine and Metabolic Science Pub Date : 2025-04-24 DOI:10.1016/j.endmts.2025.100244

Maha Elttayef Jasim , Firas Faris Rija , Sura Zahim Hussein

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Abstract

Chronic kidney disease (CKD) is major and urgent public health problem caused by a progressive reduce in renal function during some months or years which cause functional or structural abnormalities of the kidney. In renal failure, many adipokines are important in endothelial dysfunction, like inflammation and oxidative stress. This study aims to evaluate the changes of some adipokines in chronic kidney disease (CKD) with and without hemodialysis (HD) Patients. Blood samples were collected from dialysis Unit in Tikrit Teaching Hospital in Tikrit city which started from January- July 2024 who aged (18 - 68) years old. The study subjects were 90 individuals who consist of 30 healthy individuals, 30 CKD patients with hemodialysis treatment and 30 CKD patients without hemodialysis treatment. The present study showed that leptin, adiponectin and resistin were increased in CKD patients with HD and (adiponectin and resistin) were decreased in CKD patients without HD while leptin was increased in CKD patients without HD when compared with control group. Adipokines changes in hemodialysis patients rather than pre dialysis CKD patients.

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血清瘦素、脂联素和抵抗素水平与慢性肾病伴和不伴血液透析患者的关系

慢性肾脏疾病（CKD）是一种严重而紧迫的公共卫生问题，它是由几个月或几年的肾功能进行性下降引起的，导致肾脏的功能或结构异常。在肾衰竭中，许多脂肪因子在内皮功能障碍中起重要作用，如炎症和氧化应激。本研究旨在评估慢性肾脏疾病（CKD）伴和不伴血液透析（HD）患者中一些脂肪因子的变化。从2024年1月至7月在提克里特市提克里特教学医院透析室采集了年龄在（18 - 68）岁的血液样本。研究对象为90人，包括30名健康个体，30名接受血液透析治疗的CKD患者和30名未接受血液透析治疗的CKD患者。本研究显示，与对照组相比，合并HD的CKD患者瘦素、脂联素和抵抗素升高，不合并HD的CKD患者瘦素（脂联素和抵抗素）降低，而不合并HD的CKD患者瘦素升高。血液透析患者而非透析前CKD患者的脂肪因子变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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