Enhanced near-infrared Ru (II) complex fluorescence sensor for sensitive sensing of Al3+ and cell imaging

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-04-24 DOI:10.1016/j.saa.2025.126294

Longlong Li , Xiaolin Li , Xinzhi Wang , Qiang Zhang , Changsheng Zheng , Yinming Jing , Haijiao Xie

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Abstract

A near-infrared (NIR) fluorescent sensor (λ_em = 790 nm), [Ru ((CH₃O)₂bipy)₂ (BIMPY)]²⁺, was synthesized and thoroughly characterized, which can selectively recognize Al³⁺ ions in THF. The [Ru ((CH₃O)₂bipy)₂ (BIMPY)]²⁺ has excellent sensitivity (LOD = 3.48 × 10⁻⁸ mol/L) towards Al³⁺ with a 2:1 (Ru complex/Al³⁺) complex ratio and opportune binding constant (K = 606.82 mol/L). The change mechanism of photophysical properties was determined by time-dependent density functional theory (TDDFT) method, which illustrates fluorescence enhancement sensing to Al³⁺ ions. The [Ru ((CH₃O)₂bipy)₂ (BIMPY)]²⁺ was used as a field-deployable sensor, achieving on-site Al³⁺ monitoring via the RGB analysis. Furthermore, the [Ru ((CH₃O)₂bipy)₂ (BIMPY)]²⁺ succeed in imaging Al³⁺ in living HepG2 cells.

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增强型近红外Ru （II）配合物荧光传感器，用于Al3+的灵敏传感和细胞成像

合成了一种近红外（NIR）荧光传感器[Ru ((ch30)2bipy)2 (BIMPY)]2+ (λem = 790 nm)，该传感器能选择性识别THF中的Al3+离子，并对其进行了表征。[Ru ((ch30)2bipy)2 (BIMPY)]2+对Al3+具有良好的灵敏度（LOD = 3.48 × 10−8 mol/L），具有2:1 （Ru配合物/Al3+）配合物比和适宜的结合常数（K = 606.82 mol/L）。利用时间依赖密度泛函（TDDFT）方法确定了其光物理性质的变化机制，说明其对Al3+离子具有荧光增强传感。[Ru ((ch30)2bipy)2 (BIMPY)]2+被用作现场可部署传感器，通过RGB分析实现现场Al3+监测。此外，[Ru ((ch30)2bipy)2 (BIMPY)]2+在HepG2细胞中成功成像Al3+。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.