NMDA Receptors: Next therapeutic targets for Tinnitus?

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-04-26 DOI:10.1016/j.bbrep.2025.102029

Chenhao Che, Yongzhen Wu, Shan Sun

引用次数: 0

Abstract

Tinnitus, a common otological symptom, lacks clinically approved pharmacological treatments, highlighting an urgent unmet need. This review explores the potential role of NMDARs, key glutamate receptors in the auditory system, in tinnitus pathophysiology, including excitotoxicity, synaptic plasticity, and neuropathic pain. Alterations in NMDAR variants with different subunit compositions during development have also been implicated in the onset of tinnitus. Clinical trials of NMDAR antagonists, such as acamprosate, caroverine, neramexane, and AM-101, have shown promising results, though none are yet approved. These findings highlight the need for further research on NMDARs to advance the development of next-generation targeted pharmacological therapies for tinnitus.

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NMDA受体：耳鸣的下一个治疗靶点？

耳鸣是一种常见的耳科症状，缺乏临床批准的药物治疗，突出了迫切的未满足的需求。本文探讨了听觉系统中关键的谷氨酸受体NMDARs在耳鸣病理生理中的潜在作用，包括兴奋毒性、突触可塑性和神经性疼痛。发育过程中具有不同亚基组成的NMDAR变异的改变也与耳鸣的发病有关。NMDAR拮抗剂的临床试验，如阿camproate、caroverine、neramexane和AM-101，已经显示出有希望的结果，尽管尚未批准。这些发现强调了进一步研究NMDARs以推进下一代耳鸣靶向药物治疗的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.