A D–π–A featured type-I photosensitizer with NIR-II fluorescence emission for imaging-guided synergistic PDT and PTT cancer therapy

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-04-22 DOI:10.1016/j.dyepig.2025.112851

Ruohui Zhang , Wei Zhou , Di He , Weiping Zhou , Chang Liu , Ying Li , Wenzhao Han , Mengyao Li , Siyu Zhang , Cong Yu

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引用次数: 0

Abstract

Photosensitizers (PSs) with aggregation-induced emission (AIE) characteristics, near-infrared II (NIR-II) fluorescence emission, synergistic type-I photodynamic therapy (PDT) and photothermal therapy (PTT), have grown into an innovative frontier in materials and cancer research. In this study, we introduce an organic NIR-II PS named MTTCY with a donor-π-acceptor (D-π-A) structure. MTTCY exhibits a prominent capacity to generate superoxide anions (O₂^•−) and hydroxyl radicals (^•OH) upon 685 nm laser irradiation, indicating its potential for high-performance hypoxic oncotherapy. To enhance biocompatibility, an amphiphilic polymer was used to encapsulate MTTCY. The resulting nanoparticles, MTTCY NPs, display fluorescence emission extending into the NIR-II region (up to 1000 nm), high photothermal conversion efficiency (PCE) of 36.27 %, and outstanding effectiveness in producing reactive oxygen species (ROS). Utilizing 4T1 tumor-bearing mice as a model, in vivo experiments were successfully conducted, demonstrating that MTTCY NPs could effectively inhibit hypoxic tumor proliferation using NIR-II fluorescence imaging (FLI) guided type-I PDT and PTT.

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一种具有NIR-II荧光发射的D -π-A特征的i型光敏剂用于成像引导的协同PDT和PTT癌症治疗

具有聚集诱导发射（AIE）特性的光敏剂（ps）、近红外II型（NIR-II）荧光发射、协同i型光动力治疗（PDT）和光热治疗（PTT）已成为材料和癌症研究的创新前沿。在本研究中，我们引入了一种具有供体-π-受体（D-π-A）结构的有机NIR-II PS，命名为MTTCY。MTTCY在685 nm激光照射下表现出产生超氧阴离子（O2•−）和羟基自由基（•OH）的突出能力，表明其在高性能缺氧肿瘤治疗中的潜力。为了提高生物相容性，采用两亲性聚合物包封MTTCY。所制备的MTTCY NPs纳米粒子的荧光发射延伸至NIR-II区（高达1000 nm），光热转换效率（PCE）高达36.27%，并且在产生活性氧（ROS）方面具有出色的效果。以4T1荷瘤小鼠为模型，成功进行体内实验，通过NIR-II荧光成像（FLI）引导i型PDT和PTT，证明MTTCY NPs可以有效抑制缺氧肿瘤增殖。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.