Mulberry Leaf Extract and Deoxynojirimycin Modulates Glucose and Lipid Levels via the IRS1/PI3K/AKT Signaling Pathway in Cells

IF 3.5 2区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Food Biochemistry Pub Date : 2025-04-26 DOI:10.1155/jfbc/7345044

Yin-Di Zhang, Jun-Xi Liu, Fei-Fei Wang, Li-Ping Qu

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Abstract

Various diseases caused by disorders of glucose and lipid metabolism are increasing day by day. Although many drugs have certain therapeutic effects, they still produce some side effects. Therefore, this article chooses the natural medicinal plant mulberry leaves to reveal its mechanism of regulating glucose and lipid metabolism. By establishing an insulin resistance model and a 3T3-L1 adipocyte model, it was found that mulberry leaf extract (MLE) and deoxynojirimycin (DNJ) significantly increased glucose consumption and glycogen consumption, while reducing total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels. Network pharmacology, molecular docking, and protein level showed that MLE and DNJ could improve glucose and lipid metabolism disorders through IRS1/PI3K/AKT signaling pathway. These results suggest that MLE and DNJ may have broad application prospects in regulating glycolipid metabolism in functional foods and healthcare products.

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桑叶提取物和脱氧诺吉霉素通过IRS1/PI3K/AKT信号通路调节细胞内葡萄糖和脂质水平

由糖脂代谢紊乱引起的各种疾病日益增多。许多药物虽然有一定的治疗效果，但仍会产生一些副作用。因此，本文选择天然药用植物桑叶来揭示其调节糖脂代谢的机制。通过建立胰岛素抵抗模型和3T3-L1脂肪细胞模型，发现桑叶提取物（MLE）和脱氧诺吉霉素（DNJ）显著增加葡萄糖消耗和糖原消耗，同时降低总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平。网络药理学、分子对接及蛋白水平显示MLE和DNJ可通过IRS1/PI3K/AKT信号通路改善糖脂代谢紊乱。这些结果表明，MLE和DNJ在调节功能食品和保健品中的糖脂代谢方面具有广阔的应用前景。

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来源期刊

Journal of Food Biochemistry 生物-生化与分子生物学

CiteScore

7.80

自引率

5.00%

发文量

488

审稿时长

3.6 months

期刊介绍： The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet. Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes: -Biochemistry of postharvest/postmortem and processing problems -Enzyme chemistry and technology -Membrane biology and chemistry -Cell biology -Biophysics -Genetic expression -Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following: -Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease -The mechanism of the ripening process in fruit -The biogenesis of flavor precursors in meat -How biochemical changes in farm-raised fish are affecting processing and edible quality