Impact of resistance training on inflammatory biomarkers and associations with treatment outcomes in colon cancer

IF 6.1 2区医学 Q1 ONCOLOGY

Cancer Pub Date : 2025-04-25 DOI:10.1002/cncr.35865

Seohyuk Lee MD, Chao Ma MS, Bette J. Caan DrPH, Alexandra M. Binder ScD, Justin C. Brown PhD, Amalia Pena Perez BA, Catherine Lee PhD, Erin Weltzien BA, Michelle C. Ross MPH, Charles P. Quesenberry PhD, Kristin L. Campbell PhD, Elizabeth M. Cespedes Feliciano ScD, Adrienne Castillo MS, Kathryn H. Schmitz PhD, Jeffrey A. Meyerhardt MD, MPH

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Abstract

Introduction

Among patients with colon cancer undergoing adjuvant chemotherapy, the impact of resistance training with supplemental dietary protein on inflammatory changes during treatment, whether baseline or changes in inflammatory markers are associated with relative dose intensity (RDI), and the associations of inflammation with body composition were investigated.

Methods

A multicenter randomized clinical trial of 174 patients with colon cancer undergoing adjuvant chemotherapy assigned to a home-based resistance training program or usual care was conducted. High-sensitivity C-reactive protein (hsCRP), interleukin-6, tumor necrosis factor-α receptor-II, and growth differentiation factor-15 levels were assessed preintervention and following chemotherapy completion. Baseline body composition was evaluated via dual-energy X-ray absorptiometry. Multivariate analyses were adjusted for sociodemographic and clinical factors.

Results

Patients randomized to resistance training versus usual care experienced similar changes in all inflammatory markers. Those in the highest versus lowest tertile of baseline hsCRP were more likely to have received RDI >70% (odds ratio, 4.11; 95% CI, 1.29–13.1); however, changes across any of the inflammatory markers were not associated with RDI. Patients in the highest versus lowest tertiles of hsCRP, interleukin-6, and tumor necrosis factor-α receptor-II were more likely to have higher baseline body mass index, total lean mass, and total fat mass.

Conclusion

Inflammatory markers in patients with colon cancer undergoing adjuvant chemotherapy were not significantly impacted by randomization to a resistance training program but were associated with baseline body composition measures. Further investigations are needed to better elucidate the potential role of inflammatory markers and body composition in predicting important treatment outcomes.

ClinicalTrials.gov

NCT03291951

查看原文本刊更多论文

抗阻训练对结肠癌炎症生物标志物的影响及其与治疗结果的关联

在接受辅助化疗的结肠癌患者中，研究了补充膳食蛋白的抗阻训练对治疗期间炎症变化的影响，无论是基线还是炎症标志物的变化与相对剂量强度（RDI）相关，以及炎症与体成分的关系。方法对174例接受辅助化疗的结肠癌患者进行多中心随机临床试验，这些患者被分配到以家庭为基础的抗阻训练计划或常规护理。评估干预前和化疗结束后的高敏c反应蛋白（hsCRP）、白细胞介素-6、肿瘤坏死因子-α受体- ii和生长分化因子-15水平。通过双能x线吸收仪评估基线体成分。根据社会人口学和临床因素调整多变量分析。结果随机分配到抗阻训练组和常规护理组的患者在所有炎症标志物上发生了相似的变化。基线hsCRP分位数最高和最低的患者更有可能接受70%的RDI(优势比，4.11；95% ci, 1.29-13.1)；然而，任何炎症标志物的变化都与RDI无关。hsCRP、白细胞介素-6和肿瘤坏死因子-α受体- ii含量最高和最低的患者更有可能具有更高的基线体重指数、总瘦质量和总脂肪质量。结论：接受辅助化疗的结肠癌患者的炎症标志物不受随机抗阻训练计划的显著影响，但与基线体成分测量相关。需要进一步的研究来更好地阐明炎症标志物和身体成分在预测重要治疗结果中的潜在作用。ClinicalTrials.gov NCT03291951

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来源期刊

Cancer 医学-肿瘤学

CiteScore

13.10

自引率

3.20%

发文量

480

审稿时长

2-3 weeks

期刊介绍： The CANCER site is a full-text, electronic implementation of CANCER, an Interdisciplinary International Journal of the American Cancer Society, and CANCER CYTOPATHOLOGY, a Journal of the American Cancer Society. CANCER publishes interdisciplinary oncologic information according to, but not limited to, the following disease sites and disciplines: blood/bone marrow; breast disease; endocrine disorders; epidemiology; gastrointestinal tract; genitourinary disease; gynecologic oncology; head and neck disease; hepatobiliary tract; integrated medicine; lung disease; medical oncology; neuro-oncology; pathology radiation oncology; translational research