Kinga Dziadek, Mariola Drozdowska, Tomasz Kruk, Ewelina Piasna-Słupecka, Nikola Nowak-Nazarkiewicz, Wiktoria Grzebieniarz, Ewelina Jamróz
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引用次数: 0
Abstract
Glutathione, a vital antioxidant, is often limited by its rapid degradation in the gastrointestinal tract. This study introduces innovative four-layer furcellaran–chitosan microcapsules as a potential solution. By encapsulating glutathione, these microcapsules aim to protect the compound from degradation and deliver it efficiently to target tissues. Results from Wistar rats demonstrated a significant increase in serum glutathione levels when administered with encapsulated glutathione. Furthermore, the microcapsules effectively enhanced the activity and gene expression of antioxidant enzymes, suggesting improved antioxidant status. Importantly, no adverse effects were observed on liver or kidney function, indicating the safety of this approach. These findings suggest that glutathione encapsulated in furcellaran–chitosan microcapsules could be a promising strategy for supplementing glutathione deficiencies and potentially combating oxidative stress-related diseases.
期刊介绍：
The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.
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