Chemokine receptor 5 signaling in oral diseases and degenerative temporomandibular joint disease

Abstract

Background

Chemokine receptor 5 (CCR5)-mediated signals are involved in various biological responses and inflammatory diseases. Recent studies have revealed the roles of this signaling pathway in bone metabolism, metabolic bone diseases, and joint diseases.

Highlight

Through preclinical and clinical studies, our research group has demonstrated that CCR5 signaling is deeply involved in degenerative changes in the temporomandibular joint (TMJ).

Conclusion

In this short review, we outline the diverse functions of CCR5 signaling in oral and degenerative TMJ diseases.