Exploring the microRNA-mitochondrial nexus in hepatocellular carcinoma

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2025-04-24 DOI:10.1016/j.mito.2025.102045

Ali Jawad Akki , Srinivas Nanduri , Shankargouda V Patil , Kusal K Das , Prachi Parvatikar

{"title":"Exploring the microRNA-mitochondrial nexus in hepatocellular carcinoma","authors":"Ali Jawad Akki , Srinivas Nanduri , Shankargouda V Patil , Kusal K Das , Prachi Parvatikar","doi":"10.1016/j.mito.2025.102045","DOIUrl":null,"url":null,"abstract":"<div><div>MicroRNAs (miRNAs) are double-edged swords in hepatocellular carcinoma (HCC) that play a dual role in disease progression and suppression. The pivotal role of miRNAs in gene regulation emphasizes their potential to disrupt critical cellular processes, including mitochondrial function. Given the indispensable role of mitochondria in energy production, apoptosis, and metabolic control, all of which are central to HCC progression, understanding the miRNA-mitochondria axis is crucial. MiRNAs emerge as pivotal regulators of mitochondrial function, exerting profound influence over HCC progression. This comprehensive review delves into the multifaceted roles of miRNAs in modulating mitochondrial biogenesis, dynamics, and apoptosis. MiRNA impacts key metabolic pathways, including energy metabolism, fatty acid metabolism, and oxidative stress. The intricate interplay between miRNAs and mitochondrial function extends to the regulation of mitophagy and ferroptosis. By exploring the microRNA-mitochondrial axis, this review offers insights for identifying novel diagnostic and therapeutic targets.</div></div>","PeriodicalId":18606,"journal":{"name":"Mitochondrion","volume":"84 ","pages":"Article 102045"},"PeriodicalIF":3.9000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mitochondrion","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156772492500042X","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

MicroRNAs (miRNAs) are double-edged swords in hepatocellular carcinoma (HCC) that play a dual role in disease progression and suppression. The pivotal role of miRNAs in gene regulation emphasizes their potential to disrupt critical cellular processes, including mitochondrial function. Given the indispensable role of mitochondria in energy production, apoptosis, and metabolic control, all of which are central to HCC progression, understanding the miRNA-mitochondria axis is crucial. MiRNAs emerge as pivotal regulators of mitochondrial function, exerting profound influence over HCC progression. This comprehensive review delves into the multifaceted roles of miRNAs in modulating mitochondrial biogenesis, dynamics, and apoptosis. MiRNA impacts key metabolic pathways, including energy metabolism, fatty acid metabolism, and oxidative stress. The intricate interplay between miRNAs and mitochondrial function extends to the regulation of mitophagy and ferroptosis. By exploring the microRNA-mitochondrial axis, this review offers insights for identifying novel diagnostic and therapeutic targets.

查看原文本刊更多论文

探索肝细胞癌中的微 RNA-线粒体关系

MicroRNAs （miRNAs）在肝细胞癌（HCC）中是一把双刃剑，在疾病进展和抑制中发挥双重作用。mirna在基因调控中的关键作用强调了它们破坏关键细胞过程的潜力，包括线粒体功能。鉴于线粒体在能量产生、细胞凋亡和代谢控制中不可或缺的作用，所有这些都是HCC进展的核心，了解mirna -线粒体轴是至关重要的。mirna是线粒体功能的关键调节因子，对HCC的进展具有深远的影响。这篇综合综述深入研究了mirna在调节线粒体生物发生、动力学和凋亡中的多方面作用。MiRNA影响关键的代谢途径，包括能量代谢、脂肪酸代谢和氧化应激。mirna和线粒体功能之间复杂的相互作用延伸到线粒体自噬和铁下垂的调节。通过对microrna -线粒体轴的探索，本综述为确定新的诊断和治疗靶点提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.