Prognostic relation of body mass index on extended aromatase inhibition treatment in postmenopausal patients with estrogen receptor positive breast cancer: A retrospective analysis of the SOLE trial

IF 7.6 1区医学 Q1 ONCOLOGY

European Journal of Cancer Pub Date : 2025-04-17 DOI:10.1016/j.ejca.2025.115438

Giacomo Biganzoli , Edoardo Isnaldi , François Richard , Giuseppe Marano , Patrizia Boracchi , Marion Maetens , Giuseppe Floris , Patrick Neven , Guy Jerusalem , Elisabetta Munzone , Erika Hitre , Andrea Gombos , Alastair Thompson , Stefan Aebi , Roswitha Kammler , Patrizia Dell’Orto , Giuseppe Viale , Meredith M. Regan , Marco Colleoni , Elia Biganzoli , Christine Desmedt

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引用次数: 0

Abstract

Background

Obesity is associated with a greater risk of developing distant recurrences in patients with estrogen receptor-positive (ER+) breast cancer. This association is however poorly investigated in patients treated with extended endocrine treatment (ET). We therefore evaluated the prognostic role of BMI in the SOLE trial, where postmenopausal patients, after having completed 4–6 years of adjuvant ET, were treated with 5 additional years of continuous or intermittent letrozole.

Patients & methods

We considered the 3606 patients with ER+ /HER2- lymph node-positive BC with available BMI from the SOLE trial (NCT00553410). Distant-recurrence free interval (DRFI) was the main endpoint, and breast cancer-free interval (BCFI), disease-free survival (DFS) and overall survival (OS) secondary endpoints. Adjusted risk ratios (RR) for distant metastases were estimated with crude cumulative incidence models.

Results

38.6 % of the patients were underweight or normal weight, 36.5 % overweight and 24.9 % obese. BMI was associated with age, tumor size, number of positive lymph nodes, menopausal status and type of prior ET. In the adjusted analyses, the prognostic value of BMI was dependent on prior ET and extended ET arm (second-order interaction p-value<0.001 for DRFI, BCFI and DFS, but not for OS). For instance, in patients treated with both a selective estrogen receptor modulator and an aromatase inhibitor in the first five years, obesity, as compared to normal-weight, was associated with better (RR_DRFI=0.61, 95 %CI: 0.42–0.90) and worse (RR_DRFI=2.31, 95 %CI: 1.41–3.78) outcomes in the adjusted models, in patients treated with continuous and intermittent letrozole in the extended ET, respectively.

Conclusion

We observed that the prognostic relation of BMI changes according to the type of adjuvant ET and mode of administration of extended AI. This warrants further investigation.

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体重指数与绝经后雌激素受体阳性乳腺癌患者延长芳香化酶抑制治疗的预后关系：SOLE试验的回顾性分析

背景：雌激素受体阳性（ER+）乳腺癌患者的肥胖与远处复发的风险增加有关。然而，在接受延长内分泌治疗（ET）的患者中，这种关联的研究很少。因此，我们评估了BMI在SOLE试验中的预后作用，在该试验中，绝经后患者在完成4-6年的辅助ET治疗后，再接受5年的连续或间歇来曲唑治疗。的病人,方法：我们考虑了来自SOLE试验（NCT00553410）的3606例ER+ /HER2-淋巴结阳性BC患者。远处无复发间期（DRFI）为主要终点，无乳腺癌间期（BCFI）、无病生存期（DFS）和总生存期（OS）为次要终点。结果38.6% %的患者体重过轻或正常，36.5% %的患者体重过重，24.9% %的患者肥胖。BMI与年龄、肿瘤大小、阳性淋巴结数量、绝经状态和既往ET类型相关。在调整后的分析中，BMI的预后价值取决于既往ET和延长ET臂（DRFI、BCFI和DFS的二阶相互作用p值为0.001，但与OS无关）。例如，在前5年同时接受选择性雌激素受体调节剂和芳香化酶抑制剂治疗的患者中，与正常体重相比，在调整后的模型中，连续和间歇来曲唑治疗的患者分别与较好的（RRDRFI=0.61, 95 %CI: 0.42-0.90）和较差的（RRDRFI=2.31, 95 %CI: 1.41-3.78）结果相关。结论观察到BMI与预后的关系与辅助ET的类型和延长AI的给药方式有关。这值得进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Cancer 医学-肿瘤学

CiteScore

11.50

自引率

4.80%

发文量

953

审稿时长

23 days

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