Chemoselective and enantioselective fluorescent recognition of basic amino acids: A review

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-04-23 DOI:10.1016/j.dyepig.2025.112842

Fang-Qi Zhang , Zhi-Yong Xu , Yang Li , Yuan-Yuan Zhu , Shuang-Xi Gu

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Abstract

Among the 19 common chiral amino acids, three are classified as basic amino acids: histidine, arginine, and lysine, which not only play different biological functions in vivo, but also have significant value in the pharmaceutical field. It is worth noting that the L- and D-enantiomers of the same amino acids exhibit obviously different biological functions and pharmaceutical activities. Therefore, the selective recognition and analysis of basic amino acids, including chemoselective recognition and enantioselective recognition, are of great significance. Fluorescent probes have been widely used in biological and medical fields due to their excellent properties such as simplicity, real-time monitoring ability and multiple signal modes. In the past decade, significant research progress has been achieved in fluorescent probes for the selective recognition of amino acids. This paper reviews the research progress of chemoselective and enantioselective fluorescent probes for the three basic amino acids, summarizes and analyzes the probe molecular structures and recognition mechanisms, and proposes the key scientific issues and research directions to afford conducive references in the applications of fluorescent recognition of basic amino acids.

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碱性氨基酸的化学选择性和对映选择性荧光识别研究进展

在19种常见的手性氨基酸中，组氨酸、精氨酸和赖氨酸三种被归类为碱性氨基酸，它们不仅在体内发挥着不同的生物学功能，而且在制药领域也具有重要的价值。值得注意的是，同一种氨基酸的L-对映体和d -对映体表现出明显不同的生物学功能和药物活性。因此，对碱性氨基酸的选择性识别和分析，包括化学选择性识别和对映体选择性识别，具有重要意义。荧光探针具有简单、实时监测能力强、信号方式多样等优点，在生物和医学领域得到了广泛的应用。近十年来，荧光探针选择性识别氨基酸的研究取得了重大进展。本文综述了三种碱性氨基酸的化学选择性和对映选择性荧光探针的研究进展，总结和分析了探针的分子结构和识别机制，提出了关键的科学问题和研究方向，以期为碱性氨基酸荧光识别的应用提供有益的参考。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.