A wearable tool for real-time dose monitoring during cancer radiation therapies

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-04-25 DOI:10.1126/sciadv.adt7633

Ilaria Fratelli, Sara M. Carturan, Francesco Tommasino, Laura Basiricò, Felix Pino, Antonio Valletta, Marcello Campajola, Matteo Rapisarda, Sabrina Calvi, Mattia Scagliotti, Andrea Ciavatti, Luca Tortora, Enrico Verroi, Jessica C. Delgado, Lorenzo Margotti, Camilla Bordoni, Giulia Napolitano, Sandra Moretto, Alberto Aloisio, Ettore Sarnelli, Paolo Branchini, Luigi Mariucci, Alberto Quaranta, Beatrice Fraboni

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Abstract

We report on a wearable, human tissue-equivalent, real-time dosimeter designed to quantitatively monitor radiation absorbed by patients during cancer treatments. The fully organic device has been characterized under actual clinical conditions using a high-energy proton beam and an anthropomorphic phantom, with the aim to simulate a prostate cancer proton therapy treatment. We achieved a full control over the dosimeter operation, and we verified its linear response with the received dose. We demonstrate that, by a proper functionalization of the polysiloxane-based scintillator, it is possible to target the effective detection of different kinds of ionizing radiation. Specifically, besides protons, we develop a device able to detect thermal neutrons, targeting its use during Boron Neutron Capture Therapy. This work demonstrates how organic indirect detectors can be considered a universal radiation detecting platform able to monitor in real time and in situ the dose absorbed by patients during cancer treatments under different kinds of radiation.

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用于癌症放射治疗期间实时剂量监测的可穿戴工具

我们报道了一种可穿戴的人体组织等效实时剂量计，用于定量监测癌症治疗期间患者吸收的辐射。在实际临床条件下，使用高能质子束和拟人化幻影来模拟前列腺癌质子治疗的全有机装置已经被表征。我们实现了对剂量计操作的完全控制，并验证了其与接收剂量的线性响应。我们证明，通过对聚硅氧烷基闪烁体进行适当的功能化，可以有效地检测不同种类的电离辐射。具体来说，除了质子，我们还开发了一种能够探测热中子的设备，目标是在硼中子捕获治疗期间使用它。这项工作表明，有机间接探测器可以被认为是一个通用的辐射检测平台，能够实时和现场监测癌症治疗期间患者在不同类型的辐射下吸收的剂量。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.