Sensitive Detection of Acoustic Vibration at Nanometer Scale

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors Pub Date : 2025-04-24 DOI:10.1021/acssensors.5c00393

Hanyu Liu, Jinling Ma, Mingcai Xie, Weiqing Yang, Sushu Wan, Daocheng Hong, Zhihong Wei, Yuxi Tian

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Abstract

The detection of vibrations at nanometer scale is crucial for a variety of applications. The spatial resolution of acoustic detection is limited to micrometers due to its long wavelength. Single-molecule probes with a gold nanorod (GNR) have been proposed to detect an acoustic wave at the nanometer scale at room temperature. However, the detection efficiency is extremely low due to the random distribution of probe molecules and GNRs, and the detection can be used only in solid phases. In this work, we chemically linked the GNR and probe molecules using dsDNA, which provided precise distance control. Compared to the previous work, the detection sensitivity was improved by 2 orders of magnitude, approaching the theoretical detection limit, and the detection efficiency was improved from below 1% to over 95%. Furthermore, such a dsDNA connection allows sensitive detection of acoustic wave under water by a single nanodetector for “listening” to musical sounds covering two octaves. These results suggest that our achievement in precise distance control represents a significant step toward the practical application of single molecule detection of acoustic wave.

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来源期刊

ACS Sensors Chemical Engineering-Bioengineering

CiteScore

14.50

自引率

3.40%

发文量

372

期刊介绍： ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.