The epidemiological trends and survival of HPV-related oropharyngeal cancer other than tonsils and base of tongue − a systematic review and meta-analysis

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-04-25 DOI:10.1016/j.oraloncology.2025.107311

Anas Mohammad Al Fadel, Kathrine Kronberg Jakobsen, Lasse Holmgaard Jensen, Amanda-Louise Fenger Carlander, Christian Grønhøj, Christian von Buchwald

{"title":"The epidemiological trends and survival of HPV-related oropharyngeal cancer other than tonsils and base of tongue − a systematic review and meta-analysis","authors":"Anas Mohammad Al Fadel, Kathrine Kronberg Jakobsen, Lasse Holmgaard Jensen, Amanda-Louise Fenger Carlander, Christian Grønhøj, Christian von Buchwald","doi":"10.1016/j.oraloncology.2025.107311","DOIUrl":null,"url":null,"abstract":"<div><h3>Importance</h3><div>Human papillomavirus (HPV) is a well-established cause of oropharyngeal squamous cell carcinoma (OPSCC) located in the tonsils and base of tongue, but the association with other oropharyngeal subsites (otherOPSCC) remains unclear. This study aimed to examine the worldwide prevalence of HPV in otherOPSCC and its impact on survival utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.</div></div><div><h3>Methods</h3><div>The study outcomes and measures were planned at PROSPERO in advance. PubMed was searched from the earliest available record to September 1st, 2023. We included studies reporting otherOPSCC and known HPV-status. Exclusion criteria were (1) studies with ten or less otherOPSCC cases (2) studies with unspecified OPSCC subsite or with unknown primary tumor location (3) review articles, <em>meta</em>-analyses, and case reports (4) studies that focused exclusively on HPV+ or HPV- OPSCC. Two authors independently extracted the data.Risk of bias assessment was done using the ROBINS-E tool. The meta-analysis was conducted utilizing a random-effects model.</div></div><div><h3>Results</h3><div>A total of 42 studies met the inclusion criteria comprising 20 unique cohorts with a total of 6442 patients (range 11–3776). A meta-analysis showed an overall HPV prevalence of 20% (95% CI 13% 30%). We found no significant differences in the 5-year OS between HPV + otherOPSCC and HPV- otherOPSCC (56% [95% CI 29% 80%] vs 45% [95% CI 41% 49%], p = 0.43).</div></div><div><h3>Conclusion</h3><div>Our study revealed a low HPV prevalence in otherOPSCC (20%). HPV is not a useful prognostic factor in other OPSCCs than palatine tonsils and base of tongue locations.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107311"},"PeriodicalIF":4.0000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S136883752500140X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Importance

Human papillomavirus (HPV) is a well-established cause of oropharyngeal squamous cell carcinoma (OPSCC) located in the tonsils and base of tongue, but the association with other oropharyngeal subsites (otherOPSCC) remains unclear. This study aimed to examine the worldwide prevalence of HPV in otherOPSCC and its impact on survival utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines.

Methods

The study outcomes and measures were planned at PROSPERO in advance. PubMed was searched from the earliest available record to September 1st, 2023. We included studies reporting otherOPSCC and known HPV-status. Exclusion criteria were (1) studies with ten or less otherOPSCC cases (2) studies with unspecified OPSCC subsite or with unknown primary tumor location (3) review articles, meta-analyses, and case reports (4) studies that focused exclusively on HPV+ or HPV- OPSCC. Two authors independently extracted the data. Risk of bias assessment was done using the ROBINS-E tool. The meta-analysis was conducted utilizing a random-effects model.

Results

A total of 42 studies met the inclusion criteria comprising 20 unique cohorts with a total of 6442 patients (range 11–3776). A meta-analysis showed an overall HPV prevalence of 20% (95% CI 13% 30%). We found no significant differences in the 5-year OS between HPV + otherOPSCC and HPV- otherOPSCC (56% [95% CI 29% 80%] vs 45% [95% CI 41% 49%], p = 0.43).

Conclusion

Our study revealed a low HPV prevalence in otherOPSCC (20%). HPV is not a useful prognostic factor in other OPSCCs than palatine tonsils and base of tongue locations.

查看原文本刊更多论文

除扁桃体和舌底外hpv相关口咽癌的流行病学趋势和生存率——一项系统综述和荟萃分析

人乳头瘤病毒（HPV）是位于扁桃体和舌底的口咽鳞状细胞癌（OPSCC）的一个公认的病因，但与其他口咽亚位点（其他OPSCC）的关系尚不清楚。本研究旨在利用系统评价和荟萃分析（PRISMA）指南的首选报告项目，研究HPV在其他opscc中的全球患病率及其对生存的影响。方法在普洛斯佩罗提前计划研究结果和措施。PubMed从最早的可用记录到2023年9月1日进行了搜索。我们纳入了报告其他opscc和已知hpv状态的研究。排除标准为：(1)其他OPSCC病例少于10例的研究；(2)未明确OPSCC亚位点或原发肿瘤位置的研究；(3)综述文章、荟萃分析和病例报告；(4)仅关注HPV+或HPV- OPSCC的研究。两位作者独立提取了这些数据。偏倚风险评估采用ROBINS-E工具。meta分析采用随机效应模型。结果共有42项研究符合纳入标准，包括20个独特的队列，共6442例患者（范围11-3776）。一项荟萃分析显示，总体HPV患病率为20% （95% CI为13% - 30%）。我们发现HPV + otherOPSCC和HPV- otherOPSCC的5年OS无显著差异（56% [95% CI 29% 80%] vs 45% [95% CI 41% 49%], p = 0.43）。结论：我们的研究显示HPV在其他opscc中的患病率较低（20%）。与腭扁桃体和舌底位置相比，HPV不是其他OPSCCs的有用预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.