Boron-doped diamond electrochemical biosensors

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-04-10 DOI:10.1016/j.cca.2025.120285

Rafa Radithya Swara , Aqilla Irfa Muthia Rahma , Clianta Yudin Kharismasari , Dika Apriliana Wulandari , Salma Nur Zakiyyah , Yasuaki Einaga , Yeni Wahyuni Hartati , Irkham

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Abstract

Biomarkers are essential tools for identifying and monitoring disease throughout pathogenesis, diagnosis, treatment and recovery. Advanced technology, such as electrochemical biosensors, have emerged as powerful tools as sensitive, selective and cost-efficient tools to identify biomarkers. Among these, boron-doped diamond (BDD) electrodes have gained significant attention due to their functional characteristics that include wide potential window, low background current, biocompatibility and stability. These attributes enable the precise detection of biomarkers at very low concentration even in complex biologic matrices, making BDD-based biosensors uniquely suitable for clinical and point-of-care diagnostics. This review provides a comprehensive analysis of BDD electrodes, including synthesis, material properties and surface modification techniques aimed at enhancing electrochemical performance. Furthermore, the review discusses the use of BDD-based biosensors in the early detection of major diseases such as cancer, metabolic disorders and infection. By incorporating recent advancements, this article highlights the significant potential of BDD-based electrochemical biosensors in modern medical diagnostics and provides a foundation for future research.

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掺硼金刚石电化学生物传感器

生物标志物是识别和监测疾病整个发病机制、诊断、治疗和康复过程的重要工具。先进的技术，如电化学生物传感器，已经成为识别生物标志物的灵敏、选择性和成本效益的强大工具。其中，掺硼金刚石（BDD）电极因其具有宽电位窗口、低背景电流、生物相容性和稳定性等功能特点而备受关注。这些特性使得即使在复杂的生物基质中也能以非常低的浓度精确检测生物标志物，使基于bdd的生物传感器特别适合临床和护理点诊断。本文综述了BDD电极的合成、材料性能和表面改性技术，以提高其电化学性能。此外，本文还讨论了基于bdd的生物传感器在癌症、代谢紊乱和感染等重大疾病的早期检测中的应用。本文结合最新进展，强调了基于bdd的电化学生物传感器在现代医学诊断中的巨大潜力，并为未来的研究提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.