Biocompatible narrow size nanohydrogels for drug delivery

IF 4.2 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2025-04-23 DOI:10.1016/j.nano.2025.102824

Shaul D. Cemal PhD , Gila Kazimirsky MSc , Yana Shadkchan PhD , Lakshmanan Eswaran PhD , Rinat Abramovitch Prof. , Natalie Abudi PhD , Maria L. Cuestas Prof. , Nir Osherov Prof. , Gerardo Byk Prof.

{"title":"Biocompatible narrow size nanohydrogels for drug delivery","authors":"Shaul D. Cemal PhD , Gila Kazimirsky MSc , Yana Shadkchan PhD , Lakshmanan Eswaran PhD , Rinat Abramovitch Prof. , Natalie Abudi PhD , Maria L. Cuestas Prof. , Nir Osherov Prof. , Gerardo Byk Prof.","doi":"10.1016/j.nano.2025.102824","DOIUrl":null,"url":null,"abstract":"<div><div>Biodegradable polymers have gained attention for controlled drug delivery due to their potential for sustained release. Herein, a novel series of cross-linked, narrow size nanohydrogels (NHGs) with tunable sizes (20-500 nm), devoid of toxicity, and suitable for diverse biological applications were developed. These NHGs are synthesized <em>via</em> a thermo-responsive self-assembly process followed by confined polymerization. Ester cross-linkers were introduced into the polymeric backbone to enhance biodegradability. The NHGs comprise ideal candidates for drug delivery due to their long circulation in blood after <em>iv</em> administration. The anti-oxidant curcumin and the antifungal drug amphotericin B (AmB) as hydrophobic drug models were successfully loaded. The AmB-loaded NHGs showed improved antifungal activity against clinical isolates of molds and yeasts and markedly reduced morbidity in murine models inoculated with lethal doses of the pathogenic mold <em>Candida albicans</em> as compared to the commercial AmB formulation Fungizone. The NHGs thereby offer a versatile platform for controlled drug release.</div></div>","PeriodicalId":19050,"journal":{"name":"Nanomedicine : nanotechnology, biology, and medicine","volume":"66 ","pages":"Article 102824"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine : nanotechnology, biology, and medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963425000243","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Biodegradable polymers have gained attention for controlled drug delivery due to their potential for sustained release. Herein, a novel series of cross-linked, narrow size nanohydrogels (NHGs) with tunable sizes (20-500 nm), devoid of toxicity, and suitable for diverse biological applications were developed. These NHGs are synthesized via a thermo-responsive self-assembly process followed by confined polymerization. Ester cross-linkers were introduced into the polymeric backbone to enhance biodegradability. The NHGs comprise ideal candidates for drug delivery due to their long circulation in blood after iv administration. The anti-oxidant curcumin and the antifungal drug amphotericin B (AmB) as hydrophobic drug models were successfully loaded. The AmB-loaded NHGs showed improved antifungal activity against clinical isolates of molds and yeasts and markedly reduced morbidity in murine models inoculated with lethal doses of the pathogenic mold Candida albicans as compared to the commercial AmB formulation Fungizone. The NHGs thereby offer a versatile platform for controlled drug release.

Abstract Image

查看原文本刊更多论文

用于药物递送的生物相容性窄尺寸纳米水凝胶

可生物降解聚合物由于其潜在的缓释作用而引起了人们对药物控制的关注。本文开发了一系列新型的交联窄尺寸纳米水凝胶（NHGs），其尺寸可调（20-500 nm），无毒，适合多种生物应用。这些nhg是通过热响应自组装过程合成的，然后是受限聚合。在聚合物骨架中引入酯交联剂以提高生物降解性。由于NHGs在静脉给药后在血液中循环时间长，因此它是理想的药物输送候选者。成功负载了抗氧化姜黄素和抗真菌药物两性霉素B （AmB）作为疏水药物模型。与商用AmB制剂Fungizone相比，负载AmB的NHGs对霉菌和酵母菌的临床分离株具有更好的抗真菌活性，并且在接种致死剂量白色念珠菌的小鼠模型中显著降低了发病率。因此，nhg为控制药物释放提供了一个多功能平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.