THE RELATIONSHIP BETWEEN ENTAMOEBA GINGIVALIS AND TRICHOMONAS TENAX WITH PERIODONTITIS AND GINGIVITIS: A SYSTEMATIC REVIEW, META-ANALYSIS, AND META-REGRESSION

IF 4.1 4区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Evidence-Based Dental Practice Pub Date : 2025-03-25 DOI:10.1016/j.jebdp.2025.102141

Mahmood Moosazadeh PhD , Mohammad A Sabeti DDS , Seyyed Mohammad Hashemi MD , Arezoo Ghazalgoo MD , Tahoora Mousavi PhD , Seifali Mahdavi PhD , Erfan Ghadirzadeh MD

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引用次数: 0

Abstract

Introduction

Despite numerous studies investigating the link between Entamoeba gingivalis and Trichomonas tenax and periodontal diseases, findings remain inconclusive. To resolve this inconsistency, we conducted a meta-analysis to assess the association between E. gingivalis and T. tenax with both gingivitis and periodontitis.

Methods

We searched Google Scholar, Medline/PubMed, Scopus, Web of Science, and Embase search engines and databases, as well as a bibliographic section of related articles from their dates of inception to 20 April 2024. The included studies were assessed for potential biases and the overall quality of the evidence using the Newcastle-Ottawa Scale. Finally, 20 studies entered the meta-analysis.

Results

20 studies were qualified to be included in the current study. The prevalence of T. tenax was estimated to be 14% (95% CI: 8-20) among gingivitis patients and 26% (95% CI: 12-40) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with T. tenax infection than in the control group (OR: 2.30; 95% CI: 1.21-4.35, and OR: 2.90; 95% CI: 1.01-8.37, respectively). Also, the prevalence of E. gingivalis was estimated to be 45% (95% CI: 32-58) among gingivitis patients and 55% (95% CI: 35-75) in periodontitis patients. The odds of gingivitis and periodontitis were estimated to be significantly higher in patients with E. gingivalis infection than in the control group (OR: 4.08; 95% CI: 2.36-7.06, and OR: 8.33; 95% CI: 3.04-22.81, respectively).

Conclusion

Our analysis shows that individuals infected with E. gingivalis or T. tenax are more prone to periodontal diseases than noninfected individuals.

PROSPERO Registration ID

CRD42024551772

查看原文本刊更多论文

牙龈内阿米巴和毛滴虫与牙周炎和牙龈炎的关系：一项系统综述、荟萃分析和荟萃回归

引言尽管有许多研究调查了齿龈内阿米巴和肌腱毛滴虫与牙周疾病之间的联系，但研究结果仍不确定。为了解决这种不一致性，我们进行了一项荟萃分析，以评估牙龈卟啉单胞菌和T.tenax与牙龈炎和牙周炎之间的关联。方法我们搜索了Google Scholar、Medline/PubMed、Scopus、Web of Science和Embase搜索引擎和数据库，以及自其成立之日起至2024年4月20日的相关文章的书目部分。使用纽卡斯尔-渥太华量表对纳入的研究进行了潜在偏差和证据总体质量的评估。最后，20项研究进入了荟萃分析。结果20项研究符合纳入本研究的条件。在牙龈炎患者中，T.tenax的患病率估计为14%（95%CI:8-20），在牙周炎患者中为26%（95%CI:12-40）。据估计，T.tenax感染患者患牙龈炎和牙周炎的几率明显高于对照组（OR:2.30；95%CI:1.21-4.35，OR:2.90；95%CI：1.01-8.37）。此外，牙龈炎患者中牙龈单胞菌的患病率估计为45%（95%CI:32-58），牙周炎患者中为55%（95%CI:35-75）。据估计，感染牙龈单胞菌的患者患牙龈炎和牙周炎的几率明显高于对照组（OR:4.08；95%CI:2.36-7.06，OR:8.33；95%CI:3.04-22.81）。结论我们的分析表明，感染牙龈卟啉单胞菌或T.tenax的人比非感染者更容易患牙周病。PROSPERO注册号CRD42024551772

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来源期刊

Journal of Evidence-Based Dental Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

6.00

自引率

16.70%

发文量

105

审稿时长

28 days

期刊介绍： The Journal of Evidence-Based Dental Practice presents timely original articles, as well as reviews of articles on the results and outcomes of clinical procedures and treatment. The Journal advocates the use or rejection of a procedure based on solid, clinical evidence found in literature. The Journal''s dynamic operating principles are explicitness in process and objectives, publication of the highest-quality reviews and original articles, and an emphasis on objectivity.