Thiamine hydrochloride aided mechanochemical reaction: An efficient synthesis of Aryl-1,2,3-triazoles in copper ball milling conditions

Abstract

The current study investigates the catalytic efficacy of the natural organo-catalyst Vitamin B₁ (Thiamine Hydrochloride i.e. VB₁) in the synthesis of Aryl-NH-1,2,3-Triazoles utilizing Cu ball milling conditions. The reaction involving β-nitrostyrenes, trimethylsilylazide (TMSN₃), and potassium carbonate, facilitated by the VB₁ catalyst in Cu ball milling condition, has been successfully reported for the first time to yield the corresponding 4-Aryl-NH-1,2,3-Triazoles through a green chemistry approach. The methodology outlined in this study follows the concepts of green chemistry in its technique, incorporating elements such as a biodegradable catalyst, optimized ball milling conditions, reduced reaction times, high product yields, and the recyclability of both the catalyst and copper balls, all while eliminating the need for additional metal catalysts and ensuring high atom economy.