A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-04-21 DOI:10.1016/j.brainres.2025.149654

Kathleen R. Louis-Gray, Joseph A. Beatty, Charles L. Cox

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Abstract

Information transfer through the thalamus is a dynamic process, which can be influenced by multiple factors within the thalamocortical circuit. Activity-dependent changes in neuronal excitability and synaptic efficacy can impact both short- and long-term processing through the thalamocortical circuit. In these experiments, we investigate the mechanism of a novel form of post-tetanic synaptic plasticity, induced by tetanic stimulation of excitatory afferents onto thalamocortical neurons. We show that tetanic activation of excitatory afferents produces a short-lasting (10–15 min) facilitation of excitatory postsynaptic currents in ventrobasal thalamocortical neurons. This potentiation is mediated by a calcium-dependent, presynaptic mechanism. This potentiation is partly due to the activation of adenylyl cyclase and involves alteration in the hyperpolarization-activated mixed cation current, I_h. This activity-dependent facilitation of excitatory synaptic transmission provides a mechanism through which prolonged excitatory enhancement may impact sensory processing through thalamocortical circuits.

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丘脑皮质神经元短期破伤风后可塑性的新机制

信息在丘脑中的传递是一个动态过程，受丘脑皮层回路内多种因素的影响。神经元兴奋性和突触效能的活动依赖性变化可以通过丘脑皮质回路影响短期和长期加工。在这些实验中，我们研究了一种新的破伤风后突触可塑性的机制，这种可塑性是由对丘脑皮质神经元的兴奋性传入刺激引起的。我们发现，兴奋性传入事件的强直性激活在腹基底丘脑皮质神经元中产生短暂的（10-15分钟）兴奋性突触后电流的促进。这种增强是由钙依赖的突触前机制介导的。这种增强部分是由于腺苷酸环化酶的激活，并涉及到超极化激活的混合阳离子电流（Ih）的改变。这种活动依赖性的兴奋性突触传递促进提供了一种机制，通过这种机制，长时间的兴奋性增强可以通过丘脑皮质回路影响感觉加工。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.