Stress sensitization to psychological adjustment following childhood adversity: Moderation by serotonergic multilocus genetic variation

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-04-23 DOI:10.1016/j.jad.2025.04.068

Zihao Zeng , Shuangjin Liu , Qin Yang , Hongcai Wang , Zhen He , Yiqiu Hu

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引用次数: 0

Abstract

Background

Exposure to adverse childhood experiences may heighten adolescents' sensitivity to stress, which influences their psychological adjustment over their lifetimes. Some research indicates that serotonergic genetic variation moderates how environmental stressors impact psychological adjustment. However, there are recognized limitations in examining gene-environment interactions using only single polymorphisms.

Methods

The present study employed a multilocus genetic profile score (MGPS) approach to measure serotonergic genetic variations and examines their interaction with childhood abuse and friendship quality as predictors of the outcomes of psychological adjustment (depressive symptoms and sleep problems) in an adolescent sample (14.15 ± 0.63 years; N = 525).

Results

Serotonergic genetic factors moderated stress sensitivity induced by adverse childhood experiences. Adolescent psychological adjustment appeared to result from interactions between genetics and the environments. These findings were further supported by rigorous significance testing and sensitivity analyses.

Conclusion

The results highlight the strong utility of using MGPS to investigate gene-environment-environment interactions related to adolescent psychological adjustment.

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童年逆境后应激对心理调节的敏感性：血清素能多位点遗传变异的调节作用

背景童年不良经历会增加青少年对压力的敏感性，从而影响其一生的心理调整。一些研究表明，5 -羟色胺能遗传变异调节环境压力对心理调节的影响。然而，在仅使用单一多态性检查基因-环境相互作用方面存在公认的局限性。方法本研究采用多位点遗传谱评分（MGPS）方法测量5 -羟色胺能遗传变异，并检验其与童年虐待和友谊质量的相互作用作为心理适应（抑郁症状和睡眠问题）结果的预测因子。n = 525)。结果血清素能遗传因子可调节童年不良经历所致的应激敏感性。青少年的心理调整似乎是遗传和环境相互作用的结果。这些发现得到了严格的显著性检验和敏感性分析的进一步支持。结论MGPS在研究青少年心理适应相关的基因-环境-环境相互作用方面具有重要的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.