Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-04-23 DOI:10.1016/j.jad.2025.04.111

Hiba Mutwalli , Moritz Herle , Carol Kan , Johanna L. Keeler , Claire Steves , Janet Treasure , Hubertus Himmerich , Ellen J. Thompson

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引用次数: 0

Abstract

Background

The extent to which depression impacts eating behaviours, and the mechanisms underpinning their relationship are unclear. We aim to investigate the relationship between depression diagnosis and eating behaviours.

Methods

We analysed data from 1426 participants of the twins UK registry, which includes 722 monozygotic (MZ) and 702 dizygotic (DZ) twins. Eating behaviours were measured using the three-factor eating questionnaire while depression and antidepressant usage were self-reported. Co-twin control design was used to model the association between depression and eating. Sensitivity tests were implemented to exclude those using antidepressants.

Results

The heritability estimates for eating behaviours were between 35 and 41 %. Twins with a history of depression had higher scores on the emotional (d = -0.31) and constrained eating (d = -0.18). The intraclass correlations revealed a higher covariation in MZ compared to DZ twins. A moderate relationship was observed between lifetime depression and uncontrolled (β = 0.61, 95 % CI [0.17; 1.06]), emotional (β = 0.38, 95 % CI [0.22; 0.55]) and restrained eating (β = 0.43, 95 % CI [0.10; 0.77]). After removing those on antidepressants (n = 195), the relationship between eating and depression attenuated, indicating a potential influence of antidepressants in this association.

Conclusion

Our findings suggest the association between depression and eating can be partly explained by pre-existing genetic and environmental vulnerabilities. Understanding the mechanisms underlying this relationship could guide the development of effective management strategies, including personalized nutrition plans, integrated mental and dietary care, and regular monitoring to mitigate the risk of maladaptive eating behaviours and eating disorders.

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抑郁症和饮食行为的终生史：TwinsUK注册的双胎对照研究

抑郁症对饮食行为的影响程度以及两者之间关系的机制尚不清楚。我们的目的是调查抑郁症诊断和饮食行为之间的关系。方法我们分析了英国双胞胎登记处1426名参与者的数据，其中包括722对单卵双胞胎（MZ）和702对异卵双胞胎（DZ）。饮食行为采用三因素饮食问卷进行测量，而抑郁和抗抑郁药的使用情况则是自我报告。双胎对照设计用于模拟抑郁和饮食之间的关系。采用敏感性试验排除使用抗抑郁药的患者。结果饮食行为的遗传率在35% ~ 41%之间。有抑郁史的双胞胎在情绪（d = -0.31）和节制饮食（d = -0.18）方面得分更高。类内相关性显示MZ比DZ双胞胎有更高的共变异。终生抑郁与未控制抑郁之间存在中度相关性(β = 0.61, 95% CI [0.17；1.06])，情绪化(β = 0.38, 95% CI [0.22；0.55])和节制饮食(β = 0.43, 95% CI [0.10；0.77])。在去除服用抗抑郁药的患者（n = 195）后，饮食与抑郁之间的关系减弱，表明抗抑郁药在这种关联中有潜在的影响。结论：我们的研究结果表明，抑郁症和饮食之间的联系可以部分解释为先前存在的遗传和环境脆弱性。了解这种关系背后的机制可以指导制定有效的管理策略，包括个性化的营养计划，综合的精神和饮食护理，以及定期监测，以减轻饮食行为不良和饮食失调的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.