Ventilatory response and dyspnea on exertion in children with obesity and respiratory symptoms

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2025-04-22 DOI:10.1016/j.resp.2025.104437

Daniel P. Wilhite , Dharini M. Bhammar , Bryce N. Balmain , Tanya Martinez-Fernandez , Yulun Liu , Tony G. Babb

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引用次数: 0

Abstract

We investigated whether the exercise ventilatory response is associated with dyspnea on exertion (DOE) in children with (CWO;n = 25) and without (CWOO;n = 49) obesity, and with obesity and respiratory symptoms (CWORS;n = 14). The ventilatory response to exercise (V̇_E/V̇CO₂ slope) and ratings of perceived breathlessness (RPB, Borg 0–10 scale) were measured during 6-min cycling at 45 % maximal work rate. The V̇_E/V̇CO₂ slope (CWOO=34 ± 7; CWO=34 ± 5; CWORS=37 ± 6) and RPB (CWORS=4.0 ± 3.4; CWOO=2.5 ± 1.7; CWO=3.2 ± 2.1) were similar among groups (p > 0.05). A significant association between the V̇_E/V̇CO₂ slope and RPB in CWORS (r²=0.49;p < 0.05) was observed. To investigate this relationship more closely, children with an RPB≤ 2 were classified as having no or mild DOE (-DOE;n = 39;RPB=1.2 ± 0.7), and those with RPB≥ 3 were classified as having moderate to severe DOE (+DOE;n = 49;RPB=4.7 ± 1.9). +DOE had a higher V̇_E/V̇CO₂ slope (+DOE=36 ± 6;-DOE=33 ± 5;p = 0.02), higher breathing frequency, and higher V̇_E (%max;p < 0.05). These findings suggest a heightened sensitivity to ventilatory demand among children, and that +DOE may be driven by factors other than obesity alone, possibly increased ventilatory response to exercise.

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肥胖和呼吸症状患儿用力时的呼吸反应和呼吸困难

我们调查了患有（CWO;n = 25）和没有（CWOO;n = 49）肥胖以及肥胖和呼吸道症状（CWORS;n = 14）的儿童的运动通气反应是否与用力时呼吸困难（DOE）相关。在45 %最大工作速率下骑行6分钟，测量运动通气反应（V / E/V / CO2斜率）和感知呼吸困难评分（RPB， Borg 0-10评分）。V (E) /V （CO2）斜率(CWOO=34 ± 7；CWO = 34 ± 5;CWORS=37 ± 6)和RPB (CWORS=4.0 ± 3.4；CWOO = 2.5 ± 1.7;CWO=3.2 ± 2.1)组间差异无统计学意义（p >； 0.05）。CWORS的V (E) /V （CO2）斜率与RPB之间存在显著相关性（r2=0.49;p <； 0.05）。探讨这种关系更密切,孩子离≤ 2被归类为没有或轻微能源部(DOE; n = 39;强化= 1.2 ±0.7 ),和那些离≥ 3被划分中度到重度的DOE(+能源部;n = 49;强化= 4.7 ±1.9 )。+DOE具有较高的V (E) /V (E) / CO2斜率（+DOE=36 ± 6;-DOE=33 ± 5;p = 0.02）、较高的呼吸频率和较高的V (E) （%max;p <； 0.05）。这些发现表明儿童对通气需求的敏感性提高，并且+DOE可能是由肥胖以外的因素驱动的，可能是运动对通气反应的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.