Ventilatory response and dyspnea on exertion in children with obesity and respiratory symptoms

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2025-04-22 DOI:10.1016/j.resp.2025.104437

Daniel P. Wilhite , Dharini M. Bhammar , Bryce N. Balmain , Tanya Martinez-Fernandez , Yulun Liu , Tony G. Babb

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引用次数: 0

Abstract

We investigated whether the exercise ventilatory response is associated with dyspnea on exertion (DOE) in children with (CWO;n = 25) and without (CWOO;n = 49) obesity, and with obesity and respiratory symptoms (CWORS;n = 14). The ventilatory response to exercise (V̇_E/V̇CO₂ slope) and ratings of perceived breathlessness (RPB, Borg 0–10 scale) were measured during 6-min cycling at 45 % maximal work rate. The V̇_E/V̇CO₂ slope (CWOO=34 ± 7; CWO=34 ± 5; CWORS=37 ± 6) and RPB (CWORS=4.0 ± 3.4; CWOO=2.5 ± 1.7; CWO=3.2 ± 2.1) were similar among groups (p > 0.05). A significant association between the V̇_E/V̇CO₂ slope and RPB in CWORS (r²=0.49;p < 0.05) was observed. To investigate this relationship more closely, children with an RPB≤ 2 were classified as having no or mild DOE (-DOE;n = 39;RPB=1.2 ± 0.7), and those with RPB≥ 3 were classified as having moderate to severe DOE (+DOE;n = 49;RPB=4.7 ± 1.9). +DOE had a higher V̇_E/V̇CO₂ slope (+DOE=36 ± 6;-DOE=33 ± 5;p = 0.02), higher breathing frequency, and higher V̇_E (%max;p < 0.05). These findings suggest a heightened sensitivity to ventilatory demand among children, and that +DOE may be driven by factors other than obesity alone, possibly increased ventilatory response to exercise.

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.