A Smart Injectable Hydrogel with Dual Responsivity to Arginine Gingipain A and Reactive Oxygen Species for Multifunctional Therapy of Periodontitis

IF 13 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-04-24 DOI:10.1002/smll.202408034

Xuejing Li, Zhanwei Zhang, Jian Xie, Bangping Cao, Xin Wang, Yiqiang Yu, Jiansheng Su

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引用次数: 0

Abstract

Distinct clinical phenotypes of periodontitis are associated with specific microbiome profiles and diverse inflammatory conditions. Current drug delivery systems face challenges in precisely modulating this dynamic microenvironment. Effective inhibition of bone resorption can only be achieved through a strategic response to bacterial infections and inflammation within the periodontal pocket, followed by prompt treatment tailored to disease severity. In this study, tannic acid (TA) is loaded into hollow mesoporous silica nanoparticles (HMSNs) that are functionalized with positively charged polyarginines (R8) and negatively charged human serum albumin (HSA). These HMSNs‐R8@TA‐HSA (HRT) nanoparticles are then encapsulated within an injectable Nap‐Gly‐Phe‐Phe‐Tyr‐OH (NapGFFY) hydrogel (NHRT). The intermediate linker R8 can interact with both arginine gingipain A (RgpA) and reactive oxygen species (ROS), which serve as markers of bacterial infections and inflammation, respectively. HSA, arginine, TA, and nitric oxide are differentially released from the hydrogel in response to varying concentrations of RgpA and ROS, demonstrating excellent antibacterial, antioxidant, and anti‐inflammatory properties. This smart RgpA/ROS dual‐responsive and injectable hydrogel with multifunctional therapy provides new prospects for the management of periodontitis.

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一种对精氨酸愈创蛋白酶 A 和活性氧具有双重响应性的智能注射水凝胶，可用于牙周炎的多功能治疗

牙周炎的不同临床表型与特定的微生物群特征和不同的炎症条件有关。当前的给药系统在精确调节这种动态微环境方面面临挑战。有效抑制骨吸收只能通过对牙周袋内的细菌感染和炎症的战略性反应来实现，然后根据疾病的严重程度进行及时治疗。在这项研究中，单宁酸（TA）被装载到中空的介孔二氧化硅纳米颗粒（HMSNs）中，该纳米颗粒由带正电的聚精氨酸（R8）和带负电的人血清白蛋白（HSA）功能化。然后将这些HMSNs‐R8@TA‐HSA （HRT）纳米颗粒封装在可注射的Nap‐Gly‐Phe‐Phe‐Tyr‐OH （NapGFFY）水凝胶（NHRT）中。中间连接体R8可以与精氨酸牙龈蛋白酶A （RgpA）和活性氧（ROS）相互作用，这两种物质分别作为细菌感染和炎症的标志物。根据不同浓度的RgpA和ROS， HSA、精氨酸、TA和一氧化氮从水凝胶中释放出来，表现出优异的抗菌、抗氧化和抗炎特性。这种智能RgpA/ROS双响应和可注射的多功能治疗水凝胶为牙周炎的治疗提供了新的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.