Au Deposition Enhanced Fenton-like Chemistry within a Metal–Organic Framework

IF 4.3 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-04-23 DOI:10.1021/acs.inorgchem.5c01287

Zhining Yuan, Yehong Wan, Ling Zhang, Ke Jiang

引用次数: 0

Abstract

Chemodynamic therapy (CDT), which regulates oxidative stress in tumor tissues, has emerged as a promising alternative. However, the efficiency of MOF-based Fenton catalysts for CDT still needs improvement. This study presents a strategy to improve the Fenton catalytic performance of ZnCo-ZIF by depositing Au nanoparticles on its surface. Monodisperse ZnCo-ZIF particles (≤200 nm) were prepared by optimizing the Zn/Co ratio, and Au deposition enhanced electron transfer between Au and Co, increasing the charge density around Co atoms. This resulted in a 2.28-fold improvement in Fenton activity under acidic conditions and mild near-infrared (NIR) light. Loading the system with the natural product naringin (NA) molecule further demonstrated synergistic anticancer effects in vitro. This work offers insights into enhancing MOF-based catalysts for cancer therapy.

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金沉积增强了金属有机框架内的类芬顿化学

化学动力疗法（CDT），调节肿瘤组织中的氧化应激，已成为一种有前途的替代方案。然而，mof基Fenton催化剂的CDT效率仍有待提高。本研究提出了一种通过在ZnCo-ZIF表面沉积金纳米粒子来提高其Fenton催化性能的策略。通过优化Zn/Co比制备了单分散的ZnCo-ZIF粒子（≤200 nm）， Au的沉积增强了Au与Co之间的电子转移，增加了Co原子周围的电荷密度。这导致在酸性条件和轻度近红外（NIR）光下Fenton活性提高2.28倍。在体外实验中，将天然产物柚皮苷（NA）分子加载到系统中，进一步证明了协同抗癌作用。这项工作为增强mof基催化剂用于癌症治疗提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.