Comparative Analysis of Lysophosphatidic Acid Levels in Fibromyalgia and Other Painful Conditions in Female Patients

IF 3.5 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2025-04-23 DOI:10.1002/ejp.70022

Joana Menezes, Jenny E. Jakobsson, Alex Bersellini Farinotti, Emerson Krock, Matthew A. Hunt, Nils Simon, Sigita Venckute Larsson, Lars Tanum, Kim Kultima, Eva Kosek, Camilla I. Svensson

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Abstract

Background

Previous work found a decrease in lysophosphatidylcholines (LPCs) in fibromyalgia (FM) serum, prompting the hypothesis that this decrease could be due to increased conversion of LPC to lysophosphatidic acid (LPA) through autotaxin (ATX). LPA has pronociceptive functions, and increased LPA levels could modulate FM pain.

Methods

This study quantified LPA levels in serum and lumbar cerebrospinal fluid (CSF) and serum ATX levels in FM patients, comparing with healthy controls (HCs), osteoarthritis (OA), degenerative disc disease (DDD) and lumbar disc herniation (LDH) patients.

Results

We found increased serum LPA levels in FM and OA patients, with no changes in FM lumbar CSF. Unexpectedly, a positive correlation between serum LPA and conditioned pain modulation was observed in FM patients, while LPA levels were correlated with pain intensity and Knee Injury and Osteoarthritis Outcome Scores in OA. Serum ATX levels in FM patients were comparable to those in HC but correlated significantly with FM LPA levels (in one cohort), as well as with pain duration and the maximal weekly pain intensity.

Conclusions

This study suggests that increased LPA levels play distinct roles in FM and OA patients. In FM, LPA levels were linked to less impaired inhibitory pain pathways, while LPA levels in OA correlated with pain intensity and knee-related impairment. ATX levels in FM serum are associated with pain intensity and duration. These findings underscore the complex role of LPA and ATX in FM pathophysiology. Future studies are essential to clarify LPA's specific roles and to develop therapies.

Significance Statement

This study provides novel insights into the role of LPA in FM and other chronic pain conditions. Although ATX levels were unchanged in FM, a positive correlation between serum ATX and LPA supports the role of ATX in LPA conversion. These findings suggest complex lipid dysregulation in FM, with LPA potentially modulating pain pathways. Further research is needed to clarify LPA's role and its potential as a biomarker or therapeutic target.

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纤维肌痛和其他疼痛性疾病中女性患者溶血磷脂酸水平的比较分析

先前的研究发现，纤维肌痛（FM）血清中溶血磷脂酰胆碱（LPCs）减少，提示这种减少可能是由于LPC通过autotaxin （ATX）转化为溶血磷脂酸（LPA）增加所致。LPA具有前觉功能，LPA水平升高可调节FM疼痛。方法本研究量化FM患者血清、腰椎脑脊液（CSF） LPA水平及血清ATX水平，并与健康对照（hc）、骨关节炎（OA）、退行性椎间盘病（DDD）和腰椎间盘突出（LDH）患者进行比较。结果我们发现FM和OA患者血清LPA水平升高，而FM腰椎CSF无变化。出乎意料的是，在FM患者中，血清LPA与条节性疼痛调节呈正相关，而在OA患者中，LPA水平与疼痛强度、膝关节损伤和骨关节炎结局评分相关。FM患者的血清ATX水平与HC患者相当，但与FM LPA水平（在一个队列中）以及疼痛持续时间和每周最大疼痛强度显著相关。结论LPA水平升高在FM和OA患者中起着不同的作用。在FM中，LPA水平与较少受损的抑制性疼痛通路相关，而OA中的LPA水平与疼痛强度和膝关节相关损伤相关。FM血清中ATX水平与疼痛强度和持续时间有关。这些发现强调了LPA和ATX在FM病理生理中的复杂作用。未来的研究对于阐明LPA的具体作用和开发治疗方法至关重要。本研究为LPA在FM和其他慢性疼痛疾病中的作用提供了新的见解。虽然ATX水平在FM中没有变化，但血清ATX和LPA之间的正相关支持ATX在LPA转化中的作用。这些发现表明FM中复杂的脂质失调，LPA可能调节疼痛通路。需要进一步的研究来阐明LPA的作用及其作为生物标志物或治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.