Self-Esteem and Psychopathology Differentially Relate to Real-Life and Social Functioning in People With 22q11.2 Deletion Syndrome

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-04-24 DOI:10.1002/jdn.70017

Tommaso Accinni, Georgios D. Kotzalidis, Emanuele Cerulli Irelli, Massimo Pasquini, Antonino Buzzanca

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引用次数: 0

Abstract

Background

The 22q11.2 deletion syndrome (22q11.2DS) represents a genetic condition at higher risk of transition to psychosis. Both self-esteem (SE), intended as self-evaluation based on cognitive and affective elements, and psychotic symptoms may be associated with patients' real-life functioning. We investigated whether these variables differently correlate with real-life functioning in 22q11.2DS.

Methods

We recruited 22 patients with 22q11.2DS (DEL, N = 22) and 10 with 22q11.2DS and psychosis (DEL-SCZ, N = 10); we administered the Positive And Negative Syndrome Scale (PANSS), the Specific Levels of Functioning scale (SLoF) and the Self Esteem Rating Scale (SERS).

Results

The DEL-SCZ and DEL groups did not significantly differ on the SERS (p = 0.228). The DEL group scored higher than DEL-SCZ on the SLoF-total (p = 0.006) and on the SLoF-social functioning (p = 0.031). PANSS-total negatively correlated with SLoF-total scores (ρ = −0.698; p < 0.001), with the SLoF-social functioning (ρ = −0.643; p < 0.001) and with SERS (ρ = −0.391; p = 0.036). SERS scores positively correlated with SLoF-total (ρ = 0.545; p = 0.003) but not with SLoF-social functioning.

Discussion and Conclusions

DEL and DEL-SCZ display similar levels of SE suggesting that this psychological dimension is not associated with psychotic symptoms. Levels of SE and psychopathology differentially relate to real-life and social functioning in people with 22q11.2DS: Symptom severity is particularly associated with patients' social and interpersonal functioning. Psychological supportive interventions might be useful to improve real-life functioning in people with 22q11.2DS.

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22q11.2缺失综合征患者的自尊和精神病理与现实生活和社会功能的差异

22q11.2缺失综合征（22q11.2 ds）是一种向精神病过渡风险较高的遗传病。自尊（SE）是基于认知和情感因素的自我评价，而精神病症状可能与患者的现实生活功能有关。我们调查了这些变量是否与22q11.2DS的现实生活功能有不同的关联。方法选取22q11.2DS患者22例（DEL, N = 22）， 22q11.2DS合并精神病患者10例（DEL- scz, N = 10）；采用阳性和阴性症状量表（PANSS）、特定功能水平量表（SLoF）和自尊评定量表（SERS）。结果DEL- scz组与DEL组在SERS上差异无统计学意义（p = 0.228）。DEL组在slof总分（p = 0.006）和slof社会功能（p = 0.031）上得分高于DEL- scz组。panss -总分与slof -总分呈负相关(ρ = - 0.698；p < 0.001)，与slof -社会功能(ρ = - 0.643；p < 0.001)和SERS (ρ = - 0.391；p = 0.036)。SERS评分与SLoF-total呈正相关(ρ = 0.545；p = 0.003)，但与slf -社会功能无关。讨论与结论DEL和DEL- scz表现出相似的SE水平，表明这种心理维度与精神病症状无关。22q11.2DS患者的SE水平和精神病理学水平与现实生活和社会功能存在差异：症状严重程度与患者的社会和人际功能尤其相关。心理支持干预可能有助于改善22q11.2DS患者的现实生活功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.