{"title":"Exploring the impacts of nanoparticles on animal embryotoxicity: physicochemical property and bio-barrier","authors":"Yue Xu, Xiaomin Wei, Zeqiang Sun","doi":"10.1007/s11051-025-06322-1","DOIUrl":null,"url":null,"abstract":"<div><p>Wide applications of nanomaterials cause substantial environmental impacts and public concerns over their toxicity when they are intentionally (such as in medicine) or unintentionally (environment exposure) introduced into the human and animals. As a susceptible population, pregnant women are particularly vulnerable to nanoparticle-induced toxicity. However, research in this aspect is still limited and many reported findings are often inconsistent even under the “similar” experimental conditions. Here, we discuss some controversial issues which impeded further progress in this research area. Issues in the discussion are crucial effects of nanoparticles’ true identity in a physical, chemical, or biological context, and the delicate effects of gestational stages during the pregnancy.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 5","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-025-06322-1","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Wide applications of nanomaterials cause substantial environmental impacts and public concerns over their toxicity when they are intentionally (such as in medicine) or unintentionally (environment exposure) introduced into the human and animals. As a susceptible population, pregnant women are particularly vulnerable to nanoparticle-induced toxicity. However, research in this aspect is still limited and many reported findings are often inconsistent even under the “similar” experimental conditions. Here, we discuss some controversial issues which impeded further progress in this research area. Issues in the discussion are crucial effects of nanoparticles’ true identity in a physical, chemical, or biological context, and the delicate effects of gestational stages during the pregnancy.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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