A review on fumonisin B1-induced mitochondrial dysfunction and its impact on mitophagy and DNA methylation

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-04-14 DOI:10.1016/j.fct.2025.115458

Anthia C. Govender, Anil A. Chuturgoon, Terisha Ghazi

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Abstract

Fumonisin B₁ (FB₁) is a food-borne mycotoxin synthesized by Fusarium verticillioides and has been identified as a group 2B carcinogen. Recent research shows that the mitochondria and DNA in cells are targets of FB₁. Mitophagy is a form of autophagy that functions to break down impaired mitochondria to preserve the overall functionality of the cell. DNA methylation is an epigenetic process that involves the enzymatic transfer of methyl groups from S-adenosylmethionine (SAM) to the C-5 region of the DNA cytosine ring by DNA methyltransferases (DNMTs). DNA methylation plays a key role in maintaining DNA integrity and FB₁ disrupts DNA methylation via FB₁-induced folate deficiency. However, there is limited research available on the impact of FB₁ on mitophagy as well as FB₁-induced oxidative stress and its influence on DNA methylation regulation. In this review, we aim to combine and summarize the current information on FB₁-induced mitochondrial dysfunction, its impact on mitophagy as well as its DNA methylation effects.

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伏马菌素b1诱导线粒体功能障碍及其对线粒体自噬和DNA甲基化影响的研究进展

伏马菌素B1 （FB1）是由黄萎病镰刀菌合成的一种食源性真菌毒素，已被确定为2B类致癌物。最近的研究表明，细胞内的线粒体和DNA是FB1的靶点。线粒体自噬是自噬的一种形式，其功能是分解受损的线粒体，以保持细胞的整体功能。DNA甲基化是一种表观遗传过程，涉及DNA甲基转移酶（dnmt）将甲基从s -腺苷蛋氨酸（SAM）转移到DNA胞嘧啶环的C-5区域。DNA甲基化在维持DNA完整性中起关键作用，FB1通过FB1诱导的叶酸缺乏破坏DNA甲基化。然而，关于FB1对线粒体自噬的影响以及FB1诱导的氧化应激及其对DNA甲基化调控的影响的研究有限。在这篇综述中，我们旨在结合和总结目前关于fb1诱导的线粒体功能障碍，其对线粒体自噬的影响及其DNA甲基化作用的研究进展。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.