Elevated cardiometabolic index as a potential risk factor for female Urinary incontinence

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-04-22 DOI:10.1016/j.ejogrb.2025.113990

Jiameng Wang , Boyu Wang , Chengjia Li , Tianwei Meng , Yue Zhou , Jia Chen , Huifang Cong

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引用次数: 0

Abstract

Background

Urinary incontinence (UI) is closely related to metabolic conditions. The cardiometabolic index (CMI) is a novel and easily obtainable indicator used to assess metabolic status. This study aims to explore the potential relationship between CMI and female UI.

Methods

Data from the NHANES spanning seven consecutive survey cycles from 2005 to 2018 were used, including adult women who self-reported UI and had complete CMI calculation information. The CMI calculation formula is triglycerides(TG)/high-density lipoprotein cholesterol (HDL-C) × waist-to-height ratio (WHtR, WHtR = waist circumference/height). A multivariate logistic regression model was used to examine the linear relationship between CMI and UUI, SUI, and MUI, and subgroup analyses were conducted to explore potential influencing factors. Additionally, RCS curves were used to plot and analyze nonlinear relationships and threshold effects.

Results

A total of 6,628 adult women were enrolled in this study. Multivariate logistic regression showed that in the fully adjusted model, compared to subjects with the lowest CMI, those with the highest CMI had an increased association with UUI, SUI, and MUI by 1.14 times (OR = 2.14; 95 % CI, 1.83–2.50, P < 0.0001), 0.38 times (OR = 1.38; 95 % CI, 1.17–1.63, P = 0.0001), and 0.83 times (OR = 1.83; 95 % CI, 1.49–2.23, P < 0.0001), respectively. Subgroup analysis revealed significant interaction between multiple subgroups and UUI, SUI, and MUI. Additionally, the association between CMI and UUI, SUI, and MUI was nonlinear, with inflection points at 2.98, 3.21, and 2.98, respectively.

Conclusions

Elevated CMI levels are closely associated with UI and suggest that CMI may serve as a useful reference indicator for assessing UI risk; however, larger prospective cohort studies are needed to validate these findings and clarify the causal relationship between CMI and UI to advance its potential clinical application.

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心脏代谢指数升高是女性尿失禁的潜在危险因素

尿失禁（UI）与代谢状况密切相关。心脏代谢指数（CMI）是一种新的、容易获得的用于评估代谢状态的指标。本研究旨在探讨CMI与女性UI之间的潜在关系。方法采用2005 - 2018年NHANES连续7个调查周期的数据，包括自报UI并具有完整CMI计算信息的成年女性。CMI计算公式为甘油三酯(TG)/高密度脂蛋白胆固醇（HDL-C） ×腰高比（WHtR, WHtR =腰围/身高）。采用多元logistic回归模型检验CMI与UUI、SUI、MUI之间的线性关系，并进行亚组分析探讨潜在影响因素。此外，RCS曲线用于绘制和分析非线性关系和阈值效应。结果共有6628名成年女性参加了本研究。多因素logistic回归显示，在完全调整模型中，与CMI最低的受试者相比，CMI最高的受试者与UUI、SUI和MUI的相关性增加了1.14倍(OR = 2.14；95% CI, 1.83-2.50, P <；0.0001)， 0.38倍(OR = 1.38；95%置信区间,1.17 - -1.63,P = 0.0001),和0.83倍(OR = 1.83;95% CI, 1.49-2.23, P <；分别为0.0001)。亚组分析显示多个亚组与UUI、SUI和MUI之间存在显著的相互作用。此外，CMI与UUI、SUI和MUI呈非线性关系，拐点分别为2.98、3.21和2.98。结论CMI水平升高与尿失速密切相关，可作为评价尿失速风险的参考指标；然而，需要更大规模的前瞻性队列研究来验证这些发现，并澄清CMI和UI之间的因果关系，以推进其潜在的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.