Generation of human induced pluripotent stem cell lines from an age-related macular degeneration patient with hyperreflective foci overlying drusen (RFSCi002-A) and an unaffected sibling (RFSCi001-A)

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-04-15 DOI:10.1016/j.scr.2025.103715

Adnin Ashrafi , Wendy Runyon , Sam Hu , Ritu Kumar , Timothy Catchpole , Ajeet Singh , Rinki Ratnapriya , Karl G. Csaky , Srinivasa R. Sripathi

引用次数: 0

Abstract

Age-related macular degeneration (AMD) is a leading cause of vision loss, driven by retinal pigment epithelium (RPE) and photoreceptor degeneration. A key feature is drusen accumulation between the RPE and Bruch’s membrane. In intermediate AMD, hyperreflective foci (HRF)—bright intraretinal lesions visible on optical coherence tomography (OCT) imaging—serve as biomarkers of disease progression. To study HRF mechanisms, we generated induced pluripotent stem cell (iPSC) lines from an AMD patient with HRF overlying drusen (RFSC4) and their unaffected sibling (RFSC3). These iPSC models offer a platform to explore disease mechanisms and develop therapies for AMD.

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从年龄相关性黄斑变性患者（RFSCi002-A）和未受影响的兄弟姐妹（RFSCi001-A）中产生人诱导多能干细胞系

年龄相关性黄斑变性（AMD）是视力丧失的主要原因，由视网膜色素上皮（RPE）和光感受器变性驱动。一个关键特征是RPE和布鲁氏膜之间的积水。在中度AMD中，高反射灶(HRF) -光学相干断层扫描（OCT）成像可见的明亮视网膜内病变-作为疾病进展的生物标志物。为了研究HRF的机制，我们从一名HRF覆盖dren的AMD患者（RFSC4）和其未受影响的兄弟姐妹（RFSC3）中获得了诱导多能干细胞（iPSC）系。这些iPSC模型为探索AMD的疾病机制和开发治疗方法提供了一个平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.