Pharmacokinetics of Matrine in blood and prostate tissue: a microdialysis-HPLC study in a rabbit model

Q3 Pharmacology, Toxicology and Pharmaceutics

Phytomedicine Plus Pub Date : 2025-04-18 DOI:10.1016/j.phyplu.2025.100801

Yu Liu , Gefei He , Jianye Yan , Meimin Pan , Binqing Qu

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引用次数: 0

Abstract

KangFuXiaoYan suppository exhibits therapeutic potential for chronic prostatitis (CP) ,however, its in vivo pharmacokinetic process remains to be elucidated. This study investigated the pharmacokinetics of Matrine, the primary bioactive component of KangFuXiaoYan suppository, using high-performance liquid chromatography (HPLC) with microdialysis in rabbits. The results showed that the C_max of Matrine in jugular vein and prostate tissue were (86.92 ± 2.66) and (45.33 ± 3.65) mg L^-1,the T_max were (30 ± 0.00) and (45 ± 0.00) min, the T_1/2 were (23.55 ± 1.76) and (26.50 ± 5.57) min, the AUC_0-t were (4192.77 ± 67.85) and (2919.78 ± 40.17) mg min L^-1,the MRT_0-t were (48.90 ± 0.13)and (56.25 ± 1 .06) min. Matrine absorption, distribution, and penetration into prostate tissue were quantified. The results demonstrated rapid absorption into blood and prostate tissue, achieving a penetration rate of 73 %, suggesting potential therapeutic effectiveness for chronic prostatitis treatment. These findings provided experimental support for the clinical application of rectally administered KangFuXiaoYan suppository.

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苦参碱在家兔血液和前列腺组织中的药代动力学：微透析-高效液相色谱研究

康复消炎栓具有治疗慢性前列腺炎的潜力，但其体内药代动力学过程尚不清楚。采用微透析高效液相色谱法对康复消炎栓主要活性成分苦参碱在家兔体内的药动学进行了研究。结果显示，颈静脉和前列腺组织中苦参碱的Cmax分别为（86.92±2.66）和（45.33±3.65）mg L-1， Tmax分别为（30±0.00）和（45±0.00）min， T1/2分别为（23.55±1.76）和（26.50±5.57）min， AUC0-t分别为（4192.77±67.85）和（2919.78±40.17）mg min -1， MRT0-t分别为（48.90±0.13）和（56.25±1.06）min。结果表明，该药物可迅速被血液和前列腺组织吸收，渗透率达73%，提示慢性前列腺炎治疗的潜在疗效。本研究结果为直肠给药康复消炎栓的临床应用提供了实验支持。

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