Sources and components of fine air pollution exposure and brain morphology in preadolescents

Abstract

Air pollution is an emerging novel neurotoxicant during childhood and adolescence. However, little is known regarding how fine particulate matter (PM_2.5) components and its sources impact brain morphology. We investigated air pollution exposure-related differences in brain morphology using cross-sectional magnetic resonance imaging data from 10,095 children ages 9–11 years-old enrolled in the United States' Adolescent Brain Cognitive Development Study [2016–2018]. Air pollution estimates included fifteen PM_2.5 constituent chemicals and metals, and six major sources of PM_2.5 (e.g., crustal materials, biomass burning, traffic) identified from prior source apportionment, as well as nitrogen dioxide (NO₂) and ozone (O₃). After adjusting for demographic, socioeconomic, and neuroimaging covariates, we used partial least squares analyses to identify associations between simultaneous co-exposures and morphological differences in cortical thickness, surface area, and subcortical volumes. We found that greater exposure to PM_2.5 and NO₂ was associated with decreases in frontal and increases in inferior temporal surface area. PM_2.5 component and source analyses linked cortical surface area and thickness to biomass burning (e.g., organic carbon, potassium), crustal material (e.g., calcium, silicon), and traffic (e.g., copper, iron) exposures, while smaller subcortical volumes were linked to greater potassium exposure. This is the first study to show differential effects of several air pollution sources on development of children's brains. Significant associations were found in brain structures involved in several cognitive and social processes, including lower- and higher-order sensory processing, socioemotional behaviors, and executive functioning. These findings highlight differential effects of several air pollution sources on brain structure in preadolescents across the U.S.