Harmonizing Aβ deposition threshold for 18F-florbetaben PET imaging: Addressing discrepancies and calibration between PET/CT and PET/MRI

IF 8.6 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Nuclear Medicine and Molecular Imaging Pub Date : 2025-04-23 DOI:10.1007/s00259-025-07279-y

Huamei Lin, Quanling Jiang, Yunhao Yang, Qi Huang, Ying Zhang, Zhengwei Zhang, Yuhua Zhu, Jiaying Lu, Jing Wang, Min Wang, Jianwei Men, Yufeng Yang, Huiwei Zhang, Yihui Guan, Jingjie Ge, Jie Lu, Jiehui Jiang, Chuantao Zuo

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引用次数: 0

Abstract

Purpose

Discrepancies between PET/CT and PET/MRI scanners can affect the determination of amyloid beta (Aβ) deposition thresholds in patients with cognitive impairment. This study aimed to identify these differences and propose a calibration method to standardize Aβ quantification across imaging modalities.

Methods

A total of 133 patients with cognitive impairment underwent Aβ PET imaging and were divided into four groups: a head-to-head PET/CT and PET/MRI cohort (group A, n = 6), an independent PET/CT cohort (group B, n = 48), an independent PET/MRI cohort (group C, n = 79), and another independent PET/MRI cohort (group D, n = 10). Standardized uptake value ratios (SUVR) of global cortical target (CTXsuvr) and centiloid (CL) values were compared within group A and between groups B and C. A whole cerebellum (WC)-referenced SUVR method was used to calibrate CL values in group C, with verification in group D.

Results

CTXsuvr values were significantly higher in PET/MRI than in PET/CT in both group A (P < 0.05) and group C versus group B (P < 0.001). Aβ-negative/positive cases showed mean ± variance of CTXsuvr as 1.023 ± 0.104/1.479 ± 0.203 in group B and 1.146 ± 0.100/1.743 ± 0.254 in group C, with cutoffs of 1.140 (CL = 20) and 1.401 (CL = 60), respectively. WC-referenced calibration adjusted PET/MRI cutoff to 1.132 (CL = 19) in group C, aligning it with PET/CT thresholds and validated in group D.

Conclusion

WC-referenced SUVR calibration effectively mitigates differences in Aβ thresholds between PET/CT and PET/MRI, enhancing Aβ quantification standardization in multi-modal imaging.

查看原文本刊更多论文

协调18F-florbetaben PET成像的Aβ沉积阈值：解决PET/CT和PET/MRI之间的差异和校准

目的PET/CT与PET/MRI扫描的差异会影响认知障碍患者β淀粉样蛋白（Aβ）沉积阈值的测定。本研究旨在识别这些差异，并提出一种校准方法来标准化不同成像模式的a β定量。方法133例认知障碍患者行a β PET显像，分为4组：PET/CT和PET/MRI头对头组（a组，n = 6）、PET/CT独立组（B组，n = 48）、PET/MRI独立组（C组，n = 79）和PET/MRI独立组（D组，n = 10）。比较A组内和B、C组间皮质靶区（CTXsuvr）和centiloid （CL）的标准化摄取值比（SUVR），采用全小脑（WC）参考SUVR方法校准C组的CL值，并对d组进行验证。结果PET/MRI的sctxsuvr值A组显著高于PET/CT (P < 0.05)， C组显著高于B组（P < 0.001）。a β阴性/阳性病例ctxsuv均值±方差B组为1.023±0.104/1.479±0.203，C组为1.146±0.100/1.743±0.254，截止值分别为1.140 （CL = 20）和1.401 （CL = 60）。C组的PET/MRI阈值为1.132 (CL = 19)，与PET/CT阈值对齐，并在d组进行了验证。结论wc参考SUVR校准有效地缓解了PET/CT与PET/MRI之间Aβ阈值的差异，增强了多模态成像中Aβ定量的标准化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Nuclear Medicine and Molecular Imaging 医学-核医学

CiteScore

15.60

自引率

9.90%

发文量

392

审稿时长

3 months

期刊介绍： The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.