Post-COVID-19 Exacerbation of a Stable Fibrous Dysplasia: A Case Report

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Mohammed Taib Fatih, Mohammed Abdalla Mahmood, Mohammed Khalid Mahmood, Amanj Ismael Tahir, Handren Ameer Kurda, Mohammed Aso Abdulghafor, Balen Hamid Qadir, Zana Fuad Noori
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引用次数: 0

Abstract

Fibrous dysplasia (FD) is a rare, benign fibro-osseous lesion characterized by replacement of normal bone with extensive fibrous stroma due to abnormalities in osteoblast differentiation. After puberty and during adulthood, FD lesions usually become quiescent. However, some cases show signs of regrowth and reactivation. Here, we report a previously stable maxillary FD case in a 32-year-old man reactivated after a mild COVID-19 infection. We hypothesize that SARS-CoV-2 may utilize diverse mechanisms to induce tumor/cancer in multiple organs, including initiating inflammatory cascades and modifying tumor-suppressing pathways. The capacity of SARS-CoV-2 to enhance the expression of proinflammatory and tumorigenic molecules necessitates further research to ascertain any correlation between this viral infection and FD or other similar diseases.

Abstract Image

covid -19后稳定纤维发育不良加重1例报告
纤维发育不良(FD)是一种罕见的良性纤维骨性病变,其特征是由于成骨细胞分化异常而导致正常骨被广泛的纤维间质所取代。在青春期后和成年期,FD病变通常处于静止状态。然而,一些病例显示出再生和再激活的迹象。在这里,我们报告了一名32岁男性,在轻度COVID-19感染后重新激活,先前稳定的上颌FD病例。我们假设SARS-CoV-2可能利用多种机制在多个器官诱导肿瘤/癌症,包括启动炎症级联反应和改变肿瘤抑制途径。SARS-CoV-2增强促炎和致瘤分子表达的能力需要进一步研究,以确定这种病毒感染与FD或其他类似疾病之间的相关性。
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来源期刊
Clinical Case Reports
Clinical Case Reports MEDICINE, GENERAL & INTERNAL-
自引率
14.30%
发文量
1268
审稿时长
13 weeks
期刊介绍: Clinical Case Reports is different from other case report journals. Our aim is to directly improve global health and increase clinical understanding using case reports to convey important best practice information. We welcome case reports from all areas of Medicine, Nursing, Dentistry, and Veterinary Science and may include: -Any clinical case or procedure which illustrates an important best practice teaching message -Any clinical case or procedure which illustrates the appropriate use of an important clinical guideline or systematic review. As well as: -The management of novel or very uncommon diseases -A common disease presenting in an uncommon way -An uncommon disease masquerading as something more common -Cases which expand understanding of disease pathogenesis -Cases where the teaching point is based on an error -Cases which allow us to re-think established medical lore -Unreported adverse effects of interventions (drug, procedural, or other).
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