Zi-Kang Wang, Long-Xue Wang, Hao Lin, Bin Qiu, Yongchao Ma, Jian Xiao and Xiao-De An
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引用次数: 0
Abstract
Green synthesis involving visible-light EDA chemistry, multi-component systems and water as a medium is highly attractive and desirable in academia and industry. Herein, we offer a protocol to achieve a photocatalyst- and additive-free multi-component reaction driven by a cyclopropylamine-based EDA complex in water. A mechanistic study revealed that electron-deficient alkenes served as electron acceptors, enabling the formation of an EDA complex with cyclopropylamine. A series of cyclopentylamines derived from readily available cyclopropylamine, aldehyde and activated methylene species can be provided in moderate to excellent yields (up to 93%). The applicability of this method has been further demonstrated in the late-stage functionalization of a number of commercially available pharmaceutical compounds and exploration of their derivatization.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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